Table II.
Associated factors between PSA response and PSA no response.
| Factor | PSA response (n=15) | PSA no response (n=11) | P-value |
|---|---|---|---|
| Age, years | 72.33±9.68 | 74.36±10.61 | 0.616 |
| Hemoglobin, g/dl | 10.54±1.57 | 10.93±1.89 | 0.574 |
| PSA level, ng/ml | 424.38±625.90 | 214.48±230.83 | 0.301 |
| PSA nadir, ng/ml | 63.93±87.27 | 138.8±155.47 | 0.151 |
| Time to PSA nadir, months | 5.77±3.77 | 2.56±2.13 | 0.039 |
| PSA declinea | 0.17±0.11 | 0.19±0.13 | 0.787 |
| Cycles, n | 7.80±3.51 | 5.73±1.74 | 0.061 |
| Leukopenia, n (%) | 0.032 | ||
| Yes | 15 (65.20) | 8 (34.80) | |
| No | 0 (0.00) | 3 (100.00) | |
| Estramustine, n (%) | 0.391 | ||
| Yes | 8 (66.70) | 4 (33.30) | |
| No | 7 (50.00) | 7 (50.00) |
a
PSA decline = Log [(Pre-chemotherapy PSA - PSA nadir)/Survival time] where the units are as follows: PSA, ng/ml; Survival time, months.
PSA, prostate-specific antigen; SD, standard deviation.