Figure 1.

Immunohistochemistry of HER2, CCND1 and TOP2A in patients with lymph node negative breast cancer with a good and poor prognosis. Imaging was performed at ×200 magnification. HER2⁺, weak and incomplete membrane staining in >10% of cells; HER2⁺⁺, moderate and complete membrane staining in >10% of tumor cells; HER2⁺⁺⁺, strong and complete membrane staining in >10% of tumor cells. CCND1⁺ and TOP2A⁺, positive cells were 10–20%; CCND1⁺ and TOP2A⁺⁺, positive cells were 20–50% ; CCND1⁺ and TOP2A⁺⁺⁺, positive cells were >50%.