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. 2014 Jul 22;8(4):1575–1580. doi: 10.3892/ol.2014.2367

Table V.

Association between Topo II-α protein expression and Topo II-α amplification in 48 patients with laryngeal squamous cell carcinoma.

FISH

IHC Patents, n Non-amplification Amplification
(−) 15 14 1
(+) 12 11 1
(++) 17 12 5
(+++) 4 4 0

IHC, immunohistochemistry; FISH, fluorescence in situ hybridization.