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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Nanotoxicology. 2009;3(3):202–214. doi: 10.1080/17435390902859556

Table I.

Compositions of the simulated gastric and intestinal fluids

Compound Gastric (pH = 2, I = 0.07M) Concentration Intestinal (pH = 7.5, I = 0.01M) Concentration
NaCl 0.05 M
KHPO4 0.0014 M
KCl 0.0094 M 0.004 M
Pepsin 1 mg mL−1
Mucin 3 mg mL−1
CaCl2 0.0045 M
MgCl2·6 H2O 0.002 M
Urea 0.005 M
Bile salts1 9 mg mL−1
Pancreatin2 9 mg mL−1
O2 (aq) 0.00022 M 0.00022 M
EH 3 +1.02 V +0.69 V
1

Ox bile extract, consisting mainly of sodium glycocholate and sodium taurocholate

2

Contains a variety of enzymes including amylase, trypsin, lipase, ribonuclease and protease.

3

Calculated as EH = EH0 – 0.059·pH +0.01475·log[O2] with EH0 = 1.19 V (Stumm and Morgan, 1996).