TABLE 3.

Volume measurements for C. neoformans strains ATCC 24067 and H99 grown in medium alone or in medium containing 0.5 times the MIC of voriconazole

Strain	Cell		Capsule
	Mean vol ± SDa	Pb	Mean vol ± SDc	Pb
24067	132.1 ± 62.9		635.5 ± 225.7
24067 + voriconazole	89.5 ± 38.5	<0.001	137.8 ± 59.4	<0.001
H99	184.4 ± 52.4		181.0 ± 78.3
H99 + voriconazole	109.0 ± 35.3	<0.001	145.1 ± 53.2	<0.001

^aCell volume is the measurement of the cell excluding the capsule.

^bP values were calculated by using the Student's t test (n = 50) comparing the results for an individual strain with or without voriconazole.

^cCapsule volume was determined by subtracting the cell volume size from the total cell size inclusive of the polysaccharide capsule.