Figure 4. Calcium transient representation under normal and failing conditions.

Ca²⁺ transient representation in an endocardial cell (#40) (panel A), in a midmyocardial cell (#95) (panel B), and in an epicardial cell (#140) (panel C) of a heterogeneous ventricular strand for normal conditions (NC blue lines), homogeneous failing conditions (HF red lines), and heterogeneous heart failure (HF) remodeling (magenta lines). Simulations were performed using O'Hara et al. model [35].