Table 1. Basal activity and activation of WT and modified GLP-1 and GIP receptors by their respective ligands.
| pEC50 | Basal Activity (% Maximum) | |
| WT GLP-1R | 9.1±0.04 (3) | 8.8±0.5 (3) |
| GLP-1R-YFP | 8.9±0.08 (3) | 6.0±0.8 (3) |
| myc-GLP-1R | 9.3±0.4 (3) | 10.4±0.3 (3) |
| WT GIPR | 10.2±0.3 (4) | *26.0±3.7 (4) |
| GIPR-YFP | 10.0±0.1 (4) | * , #13.2±1.6 (4) |
| myc-GIPR | 9.7±0.3 (4) | ***31.1±1.0 (4) |
The mean ± S.E.M shown are from at least 3 independent experiments (the number of experiments is shown in brackets). pEC50 refers to −logEC50/M.
*Basal activity significantly higher than corresponding GLP-1R modification (P<0.05),
#
basal activity significantly lower than WT GIPR (P<0.05),
***basal activity significantly higher than the corresponding GLP-1R modification (P<0.001).