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. 2014 Sep 5;9(9):e106890. doi: 10.1371/journal.pone.0106890

Table 1. Basal activity and activation of WT and modified GLP-1 and GIP receptors by their respective ligands.

pEC50 Basal Activity (% Maximum)
WT GLP-1R 9.1±0.04 (3) 8.8±0.5 (3)
GLP-1R-YFP 8.9±0.08 (3) 6.0±0.8 (3)
myc-GLP-1R 9.3±0.4 (3) 10.4±0.3 (3)
WT GIPR 10.2±0.3 (4) *26.0±3.7 (4)
GIPR-YFP 10.0±0.1 (4) * , #13.2±1.6 (4)
myc-GIPR 9.7±0.3 (4) ***31.1±1.0 (4)

The mean ± S.E.M shown are from at least 3 independent experiments (the number of experiments is shown in brackets). pEC50 refers to −logEC50/M.

*Basal activity significantly higher than corresponding GLP-1R modification (P<0.05),

#

basal activity significantly lower than WT GIPR (P<0.05),

***basal activity significantly higher than the corresponding GLP-1R modification (P<0.001).