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. 2014 Sep 5;9(9):e107129. doi: 10.1371/journal.pone.0107129

Figure 4. NMDAR antagonists memantine and MK-801 block BBR-induced cell death.

Figure 4

NMDA receptor antagonists memantine and MK-801 block toxicity caused by 10 µM BBR in CGN and HCN cultures. (A) Representative IF images of CGN (upper row) and HCN (lower row) pretreated with memantine and MK-801 before the addition of 10 µM BBR for 6 hours. (B) Quantification of CGN viabilities shown in A. (C) Quantification of neuronal cell viability of IF images of HCN. For A, green is β-tubulin III, blue is Hoechst; the scale bars represent 100 µm. For panels B and C, n = 3. For B and C, *  = p<0.05, ***  = p<0.001.