Table 3.
Extremes analysis
Cut-off Level | |||
---|---|---|---|
>85% | >90% | >95% | |
Paranoia | |||
Co-twin means | |||
MZ | .48 (N=561) | .44 (N=367) | .42 (N=178) |
DZ | .27 (N=495) | .22 (N=312) | .22 (N=156) |
Proband Concordances | |||
MZ | .44 | .32 | .26 |
DZ | .30 | .23 | .18 |
Tetrachoric correlations | |||
MZ | .56 (.47-.63) | .47 (.36-.56) | .53 (.39-.65) |
DZ | .34 (.24-.43) | .33 (.20-.47) | .38 (.21-.54) |
DF Extremes | |||
hg2 | .42 (.24-.60) | .43 (.24-.61) | .41 (.20-.62) |
cg2 | .05 (−.09-.20) | .01 (−.13-.16) | .01 (−.16-.18) |
LT estimates | |||
h2 | .44 (.19-.63) | .27 (.00-.55) | .27 (.00-.63) |
c2 | .12 (.00-.33) | .20 (.00-.45) | .25 (.00-.54) |
e2 | .45 (.37-.53) | .53 (.44-.64) | .48 (.36-.62) |
| |||
Hallucinations | |||
Co-twin means | |||
MZ | .45 (N=546) | .40 (N=383) | .38 (N=188) |
DZ | .31 (N=493) | .27 (N=325) | .28 (N=167) |
Proband Concordances | |||
MZ | .41 | .32 | .26 |
DZ | .33 | .27 | .20 |
Tetrachoric correlations | |||
MZ | .52 (.44-.60) | .47 (.36-.56) | .50 (.35-.62) |
DZ | .39 (.29-.48) | .38 (.29-.49) | .41 (.25-.56) |
DF Extremes | |||
hg2 | .21 (.07-.40) | .22 (.04-.39) | .19 (−.03-.40) |
cg2 | .17 (−.25-.40) | .15 (−.21-.37) | .17 (−.24-.42) |
LT estimates | |||
h2 | .27 (.02-.52) | .15 (.00-.45) | .15 (.00-.55) |
c2 | .25 (.04-.46) | .32 (.06-.50) | .35 (.01-.55) |
e2 | .48 (.40-.56) | .54 (.44-.64) | .51 (.38-.63) |
| |||
Cognitive | |||
Disorganisation | |||
Co-Twin means | |||
MZ | .43 (N=681) | .34 (N=455) | .26 (N=258) |
DZ | .33 (N=670) | .27 (N=431) | .18 (N=251) |
Proband Concordances | |||
MZ | .43 | .34 | .23 |
DZ | .33 | .27 | .18 |
Tetrachoric correlations | |||
MZ | .46 (.39-.54) | .44 (.34-.53) | .37 (.24-.50) |
DZ | .24 (.14-.33) | .30 (.19-.41) | .26 (.12-.41) |
DF Extremes | |||
hg2 | .33 (.18-.49) | .30 (.13-.46) | .33 (.14-.52) |
cg2 | .10 (−.02-.22) | .13 (−.00-.26) | .06 (−.10-.21) |
LT estimates | |||
h2 | .45 (.23-.54) | .29 (.01-.53) | .22 (.00-.51) |
c2 | .00 (.00-.20) | .15 (.00-.38) | .16 (.00-.40) |
e2 | .53 (.46-.55) | .55 (.47-.65) | .62 (.50-.76) |
| |||
Grandiosity | |||
Co-twin means | |||
MZ | .50 (N=571) | .49 (N=346) | .48 (N=214) |
DZ | .25 (N=483) | .26 (N=377) | .27 (N=182) |
Proband Concordances | |||
MZ | .48 | .39 | .32 |
DZ | .29 | .25 | .18 |
Tetrachoric correlations | |||
MZ | .62 (.55-.69) | .60 (.51-.68) | .57 (.45-.67) |
DZ | .30 (.20-.42) | .32 (.21-.43) | .34 (.18-.49) |
DF Extremes | |||
hg2 | .51 (.33-.68) | .46 (.28-.65) | .41 (.21-.61) |
cg2 | −.01 (−.15-.13) | .07 (−.11-.17) | .08 (−.10-.22) |
LT estimates | |||
h2 | .62 (.37-.68) | .58 (.29-.68) | .44 (.05-.67) |
c2 | .00 (.00-.21) | .02 (.00-.25) | .13 (.00-.45) |
e2 | .38 (.32-.46) | .40 (.32-.49) | .44 (.33-.56 |
| |||
Anhedonia | |||
Co-twin means | |||
MZ | .50 (N=514) | .49 (N=295) | .46 (N=202) |
DZ | .29 (N=546) | .29 (N=277) | .30 (N=192) |
Proband Concordances | |||
MZ | .42 | .49 | .27 |
DZ | .32 | .26 | .18 |
Tetrachoric correlations | |||
MZ | .54 (.45-.61) | .51 (.40-.61) | .48 (.34-.60) |
DZ | .29 (.16-.42) | .29 (.16-.42) | .28 (.11-.44) |
DF Extremes | |||
hg2 | .41 (.24-.57) | .36 (.17-.55) | .32 (.11-.54) |
cg2 | .09 (−.04-.23) | .11 (.00-.26) | .13 (−.04-.30) |
LT estimates | |||
h2 | .51 (.25-.62) | .42 (.08-.61) | .41 (.00-.60) |
c2 | .04 (.00-.25) | .08 (.00-.61) | .07 (.00-.42) |
e2 | .46 (.38-.54) | .49 (.39-.61) | .52 (.40-.66) |
| |||
Negative symptoms | |||
Co-twin means | |||
MZ | .80 (N=578) | .81 (N=433) | .77 (N=199) |
DZ | .50 (N=525) | .44 (N=327) | .41 (N=175) |
Proband Concordances | |||
MZ | .73 | .73 | .61 |
DZ | .51 | .39 | .30 |
Tetrachoric correlations | |||
MZ | .91 (.88-.94) | .91 (.88-.94) | .86 (.80-.91) |
DZ | .60 (.51-.69) | .60 (.51-.69) | .57 (.44-.69) |
DF Extremes | |||
hg2 | .62 (.43-.81) | .74 (.55-.94) | .71 (.49-.93) |
cg2 | .19 (.03-.35) | .07 (−.09-.23) | .06 (−.12-.23) |
LT estimates | |||
h2 | .44 (.30-.60) | .59 (.41-.79) | .58 (.33-.87) |
c2 | .45 (.31-.58) | .32 (.13-.49) | .28 (.01-.51) |
e2 | .11 (.08-.14) | .09 (.06-.12) | .14 (.09-.20) |
Note. MZ=monozygotic, DZ=dizygotic, DF=DeFries-Faulker, hg2=group heritability, cg2=group shared environmental influences, LT=Liability threshold, h2=heritability estimate, c2=shared environmental estimate, e2=non-shared environmental estimate