Skip to main content
. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: JAMA Psychiatry. 2014 Sep 1;71(9):1049–1057. doi: 10.1001/jamapsychiatry.2014.994

Table 3.

Extremes analysis

Cut-off Level
>85% >90% >95%
Paranoia
Co-twin means
MZ .48 (N=561) .44 (N=367) .42 (N=178)
DZ .27 (N=495) .22 (N=312) .22 (N=156)
Proband Concordances
MZ .44 .32 .26
DZ .30 .23 .18
Tetrachoric correlations
MZ .56 (.47-.63) .47 (.36-.56) .53 (.39-.65)
DZ .34 (.24-.43) .33 (.20-.47) .38 (.21-.54)
DF Extremes
hg2 .42 (.24-.60) .43 (.24-.61) .41 (.20-.62)
cg2 .05 (−.09-.20) .01 (−.13-.16) .01 (−.16-.18)
LT estimates
h2 .44 (.19-.63) .27 (.00-.55) .27 (.00-.63)
c2 .12 (.00-.33) .20 (.00-.45) .25 (.00-.54)
e2 .45 (.37-.53) .53 (.44-.64) .48 (.36-.62)

Hallucinations
Co-twin means
MZ .45 (N=546) .40 (N=383) .38 (N=188)
DZ .31 (N=493) .27 (N=325) .28 (N=167)
Proband Concordances
MZ .41 .32 .26
DZ .33 .27 .20
Tetrachoric correlations
MZ .52 (.44-.60) .47 (.36-.56) .50 (.35-.62)
DZ .39 (.29-.48) .38 (.29-.49) .41 (.25-.56)
DF Extremes
hg2 .21 (.07-.40) .22 (.04-.39) .19 (−.03-.40)
cg2 .17 (−.25-.40) .15 (−.21-.37) .17 (−.24-.42)
LT estimates
h2 .27 (.02-.52) .15 (.00-.45) .15 (.00-.55)
c2 .25 (.04-.46) .32 (.06-.50) .35 (.01-.55)
e2 .48 (.40-.56) .54 (.44-.64) .51 (.38-.63)

Cognitive
Disorganisation
Co-Twin means
MZ .43 (N=681) .34 (N=455) .26 (N=258)
DZ .33 (N=670) .27 (N=431) .18 (N=251)
Proband Concordances
MZ .43 .34 .23
DZ .33 .27 .18
Tetrachoric correlations
MZ .46 (.39-.54) .44 (.34-.53) .37 (.24-.50)
DZ .24 (.14-.33) .30 (.19-.41) .26 (.12-.41)
DF Extremes
hg2 .33 (.18-.49) .30 (.13-.46) .33 (.14-.52)
cg2 .10 (−.02-.22) .13 (−.00-.26) .06 (−.10-.21)
LT estimates
h2 .45 (.23-.54) .29 (.01-.53) .22 (.00-.51)
c2 .00 (.00-.20) .15 (.00-.38) .16 (.00-.40)
e2 .53 (.46-.55) .55 (.47-.65) .62 (.50-.76)

Grandiosity
Co-twin means
MZ .50 (N=571) .49 (N=346) .48 (N=214)
DZ .25 (N=483) .26 (N=377) .27 (N=182)
Proband Concordances
MZ .48 .39 .32
DZ .29 .25 .18
Tetrachoric correlations
MZ .62 (.55-.69) .60 (.51-.68) .57 (.45-.67)
DZ .30 (.20-.42) .32 (.21-.43) .34 (.18-.49)
DF Extremes
hg2 .51 (.33-.68) .46 (.28-.65) .41 (.21-.61)
cg2 −.01 (−.15-.13) .07 (−.11-.17) .08 (−.10-.22)
LT estimates
h2 .62 (.37-.68) .58 (.29-.68) .44 (.05-.67)
c2 .00 (.00-.21) .02 (.00-.25) .13 (.00-.45)
e2 .38 (.32-.46) .40 (.32-.49) .44 (.33-.56

Anhedonia
Co-twin means
MZ .50 (N=514) .49 (N=295) .46 (N=202)
DZ .29 (N=546) .29 (N=277) .30 (N=192)
Proband Concordances
MZ .42 .49 .27
DZ .32 .26 .18
Tetrachoric correlations
MZ .54 (.45-.61) .51 (.40-.61) .48 (.34-.60)
DZ .29 (.16-.42) .29 (.16-.42) .28 (.11-.44)
DF Extremes
hg2 .41 (.24-.57) .36 (.17-.55) .32 (.11-.54)
cg2 .09 (−.04-.23) .11 (.00-.26) .13 (−.04-.30)
LT estimates
h2 .51 (.25-.62) .42 (.08-.61) .41 (.00-.60)
c2 .04 (.00-.25) .08 (.00-.61) .07 (.00-.42)
e2 .46 (.38-.54) .49 (.39-.61) .52 (.40-.66)

Negative symptoms
Co-twin means
MZ .80 (N=578) .81 (N=433) .77 (N=199)
DZ .50 (N=525) .44 (N=327) .41 (N=175)
Proband Concordances
MZ .73 .73 .61
DZ .51 .39 .30
Tetrachoric correlations
MZ .91 (.88-.94) .91 (.88-.94) .86 (.80-.91)
DZ .60 (.51-.69) .60 (.51-.69) .57 (.44-.69)
DF Extremes
hg2 .62 (.43-.81) .74 (.55-.94) .71 (.49-.93)
cg2 .19 (.03-.35) .07 (−.09-.23) .06 (−.12-.23)
LT estimates
h2 .44 (.30-.60) .59 (.41-.79) .58 (.33-.87)
c2 .45 (.31-.58) .32 (.13-.49) .28 (.01-.51)
e2 .11 (.08-.14) .09 (.06-.12) .14 (.09-.20)

Note. MZ=monozygotic, DZ=dizygotic, DF=DeFries-Faulker, hg2=group heritability, cg2=group shared environmental influences, LT=Liability threshold, h2=heritability estimate, c2=shared environmental estimate, e2=non-shared environmental estimate