Table 1.
N (1917) |
Mean baseline HbA1c (%) (7.75) |
Glycemic control during follow-up | ||||
---|---|---|---|---|---|---|
| ||||||
IP Arm | IS Arm | |||||
| ||||||
N (962) |
% with successful control (24.4) | N (955) |
% with successful control (35.1) |
|||
| ||||||
Baseline DM therapy groups | ||||||
None | 164 | 6.9 | 78 | 24.4 | 86 | 45.3 |
One oral agent | 577 | 7.3 | 284 | 29.2 | 293 | 57.3 |
α-glucosidase inhibitor | 1 | 5.2 | 0 | -- | 1 | 0.0 |
Sulfonylurea | 316 | 7.5 | 154 | 33.8 | 162 | 48.1 |
Meglitinide | 3 | 7.6 | 3 | 33.3 | 0 | -- |
Biguanide | 225 | 7.0 | 112 | 24.1 | 113 | 69.0 |
Thiazolidinedione | 32 | 6.9 | 15 | 20.0 | 17 | 70.6 |
Two or more oral agents | 652 | 7.8 | 327 | 22.9 | 325 | 31.1 |
Sulfonylurea + biguanide | 412 | 8.0 | 209 | 23.0 | 203 | 36.0 |
Sulfonylurea + biguanide + TZD | 133 | 7.6 | 72 | 19.4 | 61 | 14.8 |
Other combinations | 107 | 7.6 | 46 | 28.3 | 61 | 31.1 |
Insulin alone | 205 | 8.5 | 117 | 23.9 | 88 | 11.2 |
Insulin plus oral agent(s) | 319 | 8.3 | 156 | 19.2 | 163 | 11.0 |
Ins. + biguanide | 106 | 8.4 | 52 | 23.1 | 54 | 14.8 |
Ins. + sulfonylurea + biguanide | 60 | 8.3 | 25 | 20.0 | 35 | 8.6 |
Ins. + thiazolidinedione | 42 | 8.2 | 22 | 27.3 | 20 | 10.0 |
Ins. + sulfonylurea | 39 | 8.7 | 25 | 8.0 | 14 | 14.3 |
Ins. + biguanide + thiazolidinedione | 39 | 8.2 | 19 | 10.5 | 20 | 5.0 |
Other combinations | 33 | 7.9 | 13 | 23.1 | 20 | 10.0 |
| ||||||
Age at baseline, years | ||||||
<50 | 167 | 8.4 | 81 | 11.1 | 86 | 31.4 |
50-55 | 318 | 8.2 | 158 | 17.1 | 160 | 28.1 |
56-60 | 380 | 7.9 | 191 | 19.9 | 189 | 36.5 |
61-65 | 411 | 7.7 | 217 | 22.1 | 194 | 33.0 |
66-70 | 312 | 7.4 | 164 | 31.1 | 148 | 40.5 |
71+ | 329 | 7.2 | 151 | 41.1 | 178 | 39.3 |
| ||||||
Duration of diabetes at baseline, years | ||||||
0-5 | 759 | 7.4 | 370 | 23.2 | 389 | 49.1 |
6-10 | 419 | 7.8 | 198 | 23.7 | 221 | 33.9 |
11-15 | 311 | 8.2 | 162 | 25.3 | 149 | 22.8 |
16-20 | 221 | 8.1 | 111 | 25.2 | 110 | 21.8 |
21+ | 207 | 8.1 | 121 | 27.3 | 86 | 12.8 |
| ||||||
HbA1c at baseline | ||||||
<6.0% | 202 | -- | 105 | 37.1 | 97 | 60.8 |
6.0%-6.5% | 295 | -- | 139 | 30.9 | 156 | 50.6 |
6.6%-7.0% | 281 | -- | 147 | 31.2 | 134 | 45.5 |
7.1%-7.5% | 254 | -- | 121 | 26.4 | 133 | 34.6 |
7.6%-8.0% | 221 | -- | 122 | 21.3 | 99 | 28.3 |
8.1%-8.5% | 153 | -- | 80 | 17.5 | 73 | 21.9 |
8.6%-9.0% | 130 | -- | 68 | 19.1 | 62 | 25.8 |
9.1% + | 381 | -- | 180 | 11.7 | 201 | 14.9 |