Table 3. Comparison of successful long-term glycemic control between participants in the IS versus the IP arm.
Simple percentages and odds ratios (OR) of IS/IP success rates from logistic regression models
| Successful Long-Term Glycemic Control (Success) During Follow-up | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| All participants | ||||||
|
| ||||||
| IP Arm | IS Arm | OR: IS / IP | 95% C.I. | |||
|
|
|
|||||
| N | % Success | N | % Success | |||
|
| ||||||
| 962 | 24.4 | 955 | 35.1 | 1.67 | 1.37, 2.04 | |
|
| ||||||
| Insulin therapy at baseline | ||||||
| No Insulin (N=1393) | 689 | 25.7 | 704 | 43.8 | 2.25 | 1.79, 2.82 |
|
| ||||||
| Insulin (N=524) | 273 | 21.2 | 251 | 10.8 | 0.45 | 0.27, 0.73 |
|
| ||||||
| Test for heterogeneity1 of ORs | p<0.0001 | |||||
|
| ||||||
| HbA1c at baseline | ||||||
| <6.0% | 105 | 37.1 | 97 | 60.8 | 2.63 | 1.49, 4.64 |
|
| ||||||
| 6.0-6.5% | 139 | 30.9 | 156 | 50.6 | 2.29 | 1.42, 3.69 |
|
| ||||||
| 6.6-7.0% | 147 | 32.0 | 134 | 45.5 | 1.78 | 1.09, 2.89 |
|
| ||||||
| >7.0% | 571 | 18.6 | 568 | 23.9 | 1.38 | 1.04, 1.84 |
|
| ||||||
| Test for heterogeneity1 of ORs | p=0.12 | |||||
|
| ||||||
| Age at baseline | ||||||
| <50 yrs | 81 | 11.1 | 86 | 31.4 | 3.66 | 1.60, 8.38 |
|
| ||||||
| 50-60 yrs | 349 | 18.6 | 349 | 32.7 | 2.12 | 1.49, 3.01 |
|
| ||||||
| 61-70 yrs | 381 | 26.0 | 342 | 36.3 | 1.62 | 1.18, 2.23 |
|
| ||||||
| >70 yrs | 151 | 41.1 | 178 | 39.3 | 0.93 | 0.60, 1.45 |
|
| ||||||
| Test for heterogeneity1 of ORs | p=0.008 | |||||
|
| ||||||
| Duration of DM | ||||||
| < 5 yrs | 370 | 23.2 | 389 | 49.1 | 3.19 | 2.33, 4.36 |
|
| ||||||
| 5-10 yrs | 198 | 23.7 | 221 | 33.9 | 1.65 | 1.07, 2.54 |
|
| ||||||
| 11-20 yrs | 273 | 25.3 | 259 | 22.4 | 0.85 | 0.57, 1.27 |
|
| ||||||
| > 20 yrs | 121 | 27.3 | 86 | 12.8 | 0.39 | 0.19, 0.83 |
|
| ||||||
| Test for heterogeneity1 of ORs | p<0.0001 | |||||
|
| ||||||
| Level of physical activity | ||||||
| Sedentary or mild | 591 | 26.9 | 605 | 33.2 | 1.35 | 1.06, 1.73 |
|
| ||||||
| Moderate or strenuous | 371 | 20.5 | 350 | 38.3 | 2.41 | 1.73, 3.36 |
|
| ||||||
| Test for heterogeneity1 of ORs | p=0.006 | |||||
|
| ||||||
| Basal insulin | ||||||
| ≤ 5 μIU/ml** | 166 | 24.1 | 188 | 31.9 | 1.48 | 0.92, 2.36 |
|
| ||||||
| > 5 μIU/ml** | 737 | 24.4 | 710 | 35.5 | 1.70 | 1.36, 2.14 |
|
| ||||||
| Test for heterogeneity1 of ORs | p=0.59 | |||||
1
Interaction between randomization arm (IS or IP) and each row variable.
**
multiply by 6.945 to obtain pmol/L