Figure 1. Specific binding proteins recognize DNA and RNA methylations. (A) The methyl-binding proteins (MBP) recognize mammalian DNA methylation (black ball). The figure also illustrates the methylation state with binding of MBP and proteins (green and orange) that interact with MBP as well as the various transcriptional factors (purple) that control transcription. (B) The YTH domain family proteins (blue) selectively recognize internal RNA methylation (red ball). The fate of mRNA is controlled by the interplay of methyl-specific binding proteins, protein factors (pink) that interact with YTH domain family proteins, and other RNA-binding proteins (RBPs, dark blue and purple) that recognize RNA sequence and/or structure.