Table 2. Mass spectrometric identification of TSR1IP purification products (L.t.).
Protein category and accession number | Annotation | Trypanosoma brucei homolog | Number of peptides | e-value | Purifications | Reference(s) or source | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Splicing factors | ||||||||||||
1 | LmjF.34.0495 | TSR1IP | Tb927.10.2910 | 12 | 0.00000464 | SF1-Lt | 30 | |||||
2 | LmjF.07.0870 | TSR1/RBSR1 | Tb927.8.900 | 6 | 5.87E-07 | NHP2-Lt, TSR1-Lt, U2AF35-Lt | 29 | |||||
3 | LmjF.27.2100 | TRRM1 | Tb927.2.4710 | 2 | 0.005601 | TSR1-Lt, U2AF65-Tb, U2AF35-Lt | 28 | |||||
4 | LmjF.32.0400 | ATP-dependent RNA helicase, putative | Tb927.10.14550 | 6 | 1.42E-08 | CPSF73, SMN-Lt, NHP2-Lt, PRP19-Tb, U1A-Lt, Lsm3-Lt, SmD3-Lt, TSR1-Lt, U2AF65-Tb, U2AF35-Lt, SF1-Lt | 34 | |||||
5 | LmjF.07.0340 | ATP-dependent DEAD/H RNA helicase, putative | Tb927.8.1510 | 2 | 0.00000798 | CPSF73, SMN-Lt, U1A-Lt, Lsm3-Lt, SmD3-Lt, TSR1-Lt, U2AF35-Lt, SF1-Lt | 34 | |||||
mRNA metabolism | ||||||||||||
6 | LmjF.35.5040 | PABP1 | Tb09.211.0930 | 1 | 0.000261 | NHP2-Lt, U1A-Lt, SmB-Tb,65 SmD1-Tb,38 SmD3-Lt, TSR1-Lt, U2AF35-Lt | 82 , 83 | |||||
7 | LmjF.35.4130 | PABP2 | Tb09.211.2150 | 6 | 0.000178 | NHP2-Lt, PRP19-Tb, SmB-Tb,65 SmD1-Tb,38 SmD3-Lt, TSR1-Lt, U2AF35-Lt | 84 | |||||
8 | LmjF.25.0080 | PABP | ** | 3 | 0.000073 | NHP2-Lt, SmB-Tb,65 SmD1-Tb,38 SmD3-Lt, TSR1-Lt, U2AF35-Lt | GeneDB | |||||
9 | LmjF.35.2200 | DRBD2 | Tb09.211.4540 | 2 | 0.008095 | NHP2-Lt, TSR1-Lt, U2AF35-Lt | 85 | |||||
10 | LmjF.09.1120 | MRP2 | Tb11.01.4860 | 1 | 0.006042 | TSR1-Lt, U2AF35-Lt | 49 , 89 | |||||
11 | LmjF.19.1270 | RNA binding protein, putative | Tb927.10.15870 | 2 | 0.00000954 | GeneDB | ||||||
12 | LmjF.35.0370 | DHH1 | Tb927.10.3990 | 1 | 0.002744 | CPSF73, SMN-Lt, U1A-Lt, Lsm3-Lt, SmD3-Lt, TSR1-Lt, U2AF35-Lt, SF1-Lt | 90 | |||||
Ribosomal biogenesis and assembly proteins | ||||||||||||
13 | LmjF.32.0750 | NRBD2/P37 | Tb11.01.5590 | 1 | 0.0000288 | TSR1-Lt, U2AF35-Lt | 91 | |||||
Helicases | ||||||||||||
14 | LmjF.27.1300 (p58) | hypothetical protein, conserved | Tb11.46.0009 | 2 | 0.000324 | NHP2-Lt, TSR1-Lt, U2AF35-Lt | GeneDB | |||||
Hypothetical proteins | ||||||||||||
15 | LmjF.35.5390 | hypothetical protein, conserved | Tb927.4.310 | 1 | 0.005682 | TSR1-Lt, U2AF35-Lt, SF1-Lt | GeneDB | |||||
16 | LmjF.35.4870 | hypothetical protein, conserved | Tb09.211.1230 | 1 | 0.0000148 | SF1-Lt | GeneDB | |||||
17 | LmjF.08.0340 | hypothetical protein, conserved | Tb927.5.3330 | 1 | 0.007234 | SF1-Lt | GeneDB |
L. tarentolae proteins were identified by mass spectroscopy as described in Materials and Methods. Each protein is identified by its accession number (http://www.genedb.org), annotation, T. brucei homolog, numbers of peptides, other purifications revealing the same protein, and reference. Proteins were grouped into splicing factors, mRNA metabolism, ribosomal biogenesis and assembly proteins, helicases and hypothetical proteins. The e-value reflects probability of identification of the protein by the MS data.