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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Lancet. 2012 Dec 15;380(9859):2224–2260. doi: 10.1016/S0140-6736(12)61766-8

Table 3.

Deaths attributable to risk factors and risk factor clusters, worldwide

Men Women Both sexes



1990 2010 1990 2010 1990 2010
Unimproved water and sanitation 365 244 (18 940–662 551) 171 097 (6841–326 262) 350 629 (17 531–638 433) 166 379 (6690–326 989) 715 873 (36 817–1 279 220) 337 476 (13 150–648 205)
  Unimproved water source 147 857 (10 566–282 890) 59 463 (3880–120 264) 140 150 (10 042–271 546) 56 663 (3604–115 704) 288 007 (20 641–553 293) 116 126 (7518–233 136)
  Unimproved sanitation 252 779 (8032–480 822) 123 255 (2924–242 588) 244 207 (7348–460 913) 120 851 (3104–242 452) 496 986 (15 380–927 845) 244 106 (6027–478 186)

Air pollution
  Ambient particulate matter pollution 1 549 448 (1 345 894–1 752 880) 1 850 428 (1 614 010–2 082 474) 1 360 712 (1 166 992–1 559 747) 1 373 113 (1 187 639–1 563 793) 2 910 161 (2 546 184–3 286 508) 3 223 540 (2 828 854–3 619 148)
  Household air pollution from solid fuels 2 309 166 (1 720 246–2 824 893) 1 900 443 (1 378 832–2 518 572) 2 270 549 (1 889 651–2 655 411) 1 645 956 (1 265 509–2 089 785) 4 579 715 (3 717 711–5 365 013) 3 546 399 (2 679 627–4 516 722)
  Ambient ozone pollution 77 087 (25 256–134 021) 86 335 (30 551–153 776) 66 274 (22 424–116 663) 66 100 (21 362–115 225) 143 362 (47 539–251 885) 152 434 (52 272–267 431)

Other environmental risks 109 224 (91 805–131 511) 426 280 (341 744–541 465) 100 699 (82 720–119 745) 346 751 (281 555–413 370) 209 923 (177 673–243 565) 773 030 (640 893–929 935)
  Residential radon 70 014 (9140–154 460) 28 978 (4098–64 387) 98 992 (13 133–215 237)
  Lead exposure 109 224 (91 805–131 511) 356 266 (292 587–435 046) 100 699 (82 720–119 745) 317 772 (265 722–376 431) 209 923 (177 673–243 565) 674 038 (575 858–779 314)

Child and maternal undernutrition 1 805 224 (1 479 043–2 219 888) 739 863 (570 560–909 248) 1 668 365 (1 396 689–1 986 532) 698 442 (569 013–832 012) 3 473 589 (2 906 896–4 175 138) 1 438 305 (1 175 257–1 713 103)
  Suboptimal breastfeeding 693 103 (427 028–972 440) 293 449 (175 623–429 772) 581 921 (370 598–814 551) 251 368 (155 884–359 651) 1 275 024 (802 142–1 772 745) 544 817 (338 453–775 077)
    Non-exclusive breastfeeding 612 059 (354 236–875 230) 257 771 (143 116–382 459) 505 849 (302 585–720 858) 218 117 (126 383–319 470) 1 117 908 (663 274–1 576 633) 475 888 (272 493–684 422)
    Discontinued breastfeeding 81 044 (8643–178 237) 35 678 (3475–79 940) 76 073 (7809–165 395) 33 251 (3091–73 804) 157 117 (16 188–341 702) 68 929 (6445–153 290)
  Childhood underweight 1 198 178 (997 627–1 484 105) 458 639 (366 866–561 352) 1 065 774 (898 859–1 299 715) 401 478 (325 516–484 452) 2 263 952 (1 927 356–2 735 821) 860 117 (715 742–1 033 573)
  Iron deficiency 39 409 (30 677–47 108) 32 287 (21 925–37 449) 128 675 (92 036–156 884) 87 321 (62 505–107 021) 168 084 (130 444–197 085) 119 608 (93 261–139 985)
  Vitamin A deficiency 181 151 (85 775–341 439) 63 291 (32 070–104 030) 168 203 (80 696–298 163) 56 472 (28 192–91 464) 349 354 (170 504–632 149) 119 762 (61 723–191 846)
  Zinc deficiency 143 518 (27 797–276 850) 52 390 (9382–105 728) 132 071 (23 716–253 841) 44 940 (7696–87 711) 275 590 (51 274–529 451) 97 330 (17 575–190 527)

Tobacco smoking (including second-hand smoke) 3 680 571 (3 213 427–4 229 530) 4 507 059 (3 757 779–5 092 460) 1 649 238 (1 380 504–2 144 408) 1 790 228 (1 278 666–2 094 260) 5 329 808 (4 778 526–6 049 296) 6 297 287 (5 395 769–7 006 942)
  Tobacco smoking 3 332 192 (2 871 957–3 840 033) 4 251 424 (3 503 674–4 850 554) 1 244 106 (961 356–1 781 819) 1 443 924 (920 763–1 743 849) 4 576 298 (4 068 753–5 312 438) 5 695 349 (4 755 779–6 421 611)
  Second-hand smoke 348 378 (273 555–425 310) 255 634 (191 587–314 541) 405 132 (310 224–500 100) 346 304 (252 702–439 439) 753 510 (585 131–912 313) 601 938 (447 705–745 328)

Alcohol and drug use 2 367 579 (2 201 233–2 555 818) 3 249 978 (3 004 655–3 488 393) 1 394 778 (1 245 021–1 545 612) 1 768 073 (1 588 197–1 935 072) 3 762 356 (3 508 021–4 030 022) 5 018 051 (4 680 954–5 321 362)
  Alcohol use 2 325 747 (2 153 733–2 512 207) 3 140 109 (2 902 204–3 376 483) 1 374 578 (1 223 155–1 522 080) 1 720 059 (1 541 469–1 886 125) 3 700 324 (3 451 511–3 967 436) 4 860 168 (4 533 106–5 153 283)
  Drug use 46 682 (33 063–78 398) 109 420 (82 297–152 421) 21 895 (15 984–31 023) 48 385 (36 780–64 303) 68 577 (50 706–102 395) 157 805 (124 639–209 873)

Physiological risk factors
  High fasting plasma glucose 1 051 401 (865 949–1 250 550) 1 749 058 (1 455 169–2 039 206) 1 052 773 (881 704–1 230 327) 1 607 214 (1 367 465–1 839 764) 2 104 174 (1 797 633–2 401 170) 3 356 271 (2 917 520–3 782 483)
  High total cholesterol 936 749 (767 684–1 128 051) 961 614 (714 774–1 236 023) 1 009 172 (829 163–1 218 442) 1 057 196 (793 595–1 350 633) 1 945 920 (1 625 929–2 318 054) 2 018 811 (1 572 853–2 479 097)
  High blood pressure 3 412 588 (3 089 548–3 769 223) 4 750 581 (4 272 529–5 273 576) 3 880 598 (3 559 634–4 250 099) 4 645 279 (4 198 029–5 092 003) 7 293 185 (6 701 203–7 859 894) 9 395 860 (8 579 630–10 147 805)
  High body-mass index 887 047 (698 599–1 079 235) 1 632 766 (1 328 501–1 941 988) 1 076 502 (878 065–1 286 482) 1 738 466 (1 454 008–2 036 059) 1 963 549 (1 590 282–2 345 133) 3 371 232 (2 817 774–3 951 127)
  Low bone mineral density 52 816 (43 822–69 605) 103 440 (67 743–124 596) 50 455 (40 408–62 110) 84 146 (57 863–102 441) 103 270 (90 672–124 230) 187 586 (140 636–219 906)

Dietary risk factors and physical inactivity 4 473 276 (4 110 262–4 852 556) 6 687 621 (6 172 230–7 206 283) 4 057 558 (3 704 325–4 431 571) 5 815 748 (5 380 274–6 261 225) 8 530 835 (7 907 898–9 150 862) 12 503 370 (11 710 741–13 324 770)
  Diet low in fruits 2 013 415 (1 570 347–2 435 112) 2 837 481 (2 203 651–3 414 649) 1 653 787 (1 269 335–2 006 693) 2 064 761 (1 593 495–2 507 876) 3 667 202 (2 870 267–4 394 152) 4 902 242 (3 818 356–5 881 561)
  Diet low in vegetables 779 747 (535 472–1 041 517) 1 017 500 (687 787–1 378 721) 674 309 (441 649–910 150) 779 754 (521 285–1 040 304) 1 454 057 (978 665–1 924 334) 1 797 254 (1 205 059–2 394 366)
  Diet low in whole grains 649 676 (503 984–787 057) 963 640 (748 116–1 162 721) 580 600 (447 140–706 303) 762 171 (592 879–919 709) 1 230 276 (958 136–1 489 812) 1 725 812 (1 342 896–2 067 224)
  Diet low in nuts and seeds 1 041 726 (667 481–1 349 266) 1 389 433 (890 869–1 817 734) 872 483 (541 757–1 147 258) 1 082 390 (663 158–1 441 054) 1 914 209 (1 216 363–2 487 874) 2 471 823 (1 559 603–3 226 994)
  Diet low in milk 34 838 (10 464–58 211) 54 093 (16 106–91 527) 33 312 (9745–57 799) 46 858 (13 085–80 413) 68 150 (20 479–114 435) 100 951 (29 728–171 340)
  Diet high in red meat 13 888 (3859–23 763) 21 330 (6175–37 340) 12 551 (3425–22 054) 16 762 (4306–29 007) 26 439 (7374–45 232) 38 092 (10 749–65 727)
  Diet high in processed meat 397 198 (85 536–688 905) 473 562 (103 608–842 923) 334 476 (71 692–584 050) 367 296 (83 446–637 120) 731 675 (158 044–1 257 423) 840 857 (188 952–1 460 279)
  Diet high in sugar-sweetened beverages 100 250 (69 485–134 139) 161 042 (111 700–219 563) 83 548 (53 949–117 567) 138 480 (91 257–203 236) 183 799 (127 938–240 028) 299 521 (212 310–403 716)
  Diet low in fibre 333 603 (149 007–521 712) 441 895 (201 062–693 234) 250 541 (111 867–394 088) 300 994 (134 201–470 634) 584 144 (260 065–914 729) 742 888 (334 379–1 166 933)
  Diet low in calcium 48 975 (32 814–66 562) 76 413 (51 653–103 188) 33 330 (23 008–43 904) 49 181 (34 016–63 592) 82 305 (57 324–108 535) 125 594 (88 323–164 800)
  Diet low in seafood omega-3 fatty acids 576 646 (418 376–735 746) 793 650 (574 241–1 010 930) 466 440 (337 205–601 988) 596 246 (437 287–764 762) 1 043 085 (757 418–1 327 627) 1 389 896 (1 010 300–1 781 401)
  Diet low in polyunsaturated fatty acids 248 677 (117 929–381 787) 306 296 (140 873–473 149) 199 388 (95 418–305 733) 227 307 (108 675–350 194) 448 065 (213 262–687 396) 533 603 (245 096–820 854)
  Diet high in trans fatty acids 202 725 (144 395–260 843) 293 087 (209 155–371 284) 164 736 (117 395–211 588) 222 173 (160 511–283 740) 367 461 (265 936–467 609) 515 260 (371 081–649 451)
  Diet high in sodium 1 197 713 (776 962–1 589 448) 1 732 870 (1 122 107–2 301 781) 1 047 642 (666 779–1 397 486) 1 371 438 (878 780–1 834 541) 2 245 355 (1 459 900–2 966 107) 3 104 308 (2 016 734–4 105 019)
  Physical inactivity and low physical activity 1 547 833 (1 264 464–1 835 192) 1 636 107 (1 369 722–1 899 182) 3 183 940 (2 657 204–3 718 963)

Occupational risk factors 694 403 (541 113–858 435) 749 857 (580 954–941 322) 116 743 (74 642–164 679) 102 250 (68 744–140 097) 811 146 (623 674–1 010 107) 852 107 (659 652–1 062 443)
  Occupational carcinogens 55 306 (37 867–80 887) 92 154 (57 261–127 678) 16 766 (11 866–24 842) 25 943 (15 498–37 074) 72 073 (50 753–101 233) 118 097 (77 249–160 431)
    Occupational exposure to asbestos 17 024 (11 044–26 605) 26 563 (14 454–36 593) 6033 (4012–9397) 7047 (3312–9681) 23 057 (16 939–33 009) 33 610 (20 317–43 647)
    Occupational exposure to arsenic 1155 (446–2210) 1915 (717–3496) 463 (176–915) 747 (275–1402) 1618 (622–3039) 2662 (1011–4860)
    Occupational exposure to benzene 993 (426–1757) 1542 (618–2706) 770 (292–1422) 1189 (434–2156) 1764 (741–3085) 2731 (1111–4811)
    Occupational exposure to beryllium 61 (24–110) 114 (44–192) 26 (10–47) 49 (19–86) 87 (35–152) 163 (65–276)
    Occupational exposure to cadmium 214 (97–370) 410 (179–670) 74 (33–130) 145 (62–245) 288 (131–494) 555 (249–901)
    Occupational exposure to chromium 729 (431–1133) 1361 (720–2014) 293 (171–490) 570 (295–858) 1022 (618–1578) 1931 (1140–2799)
    Occupational exposure to diesel engine exhaust 10 979 (6241–17 555) 18 773 (9641–28 714) 2060 (1180–3422) 3413 (1709–5262) 13 040 (7494–20 486) 22 187 (12 180–33 213)
    Occupational exposure to second-hand smoke 10 171 (6878–15 272) 17 189 (10 127–23 037) 3854 (2637–6207) 7046 (3935–9630) 14 025 (10 058–19 715) 24 235 (16 094–31 803)
    Occupational exposure to formaldehyde 299 (117–584) 486 (185–939) 179 (77–325) 245 (97–456) 478 (202–877) 731 (301–1361)
    Occupational exposure to nickel 3578 (935–7585) 6443 (1616–13 317) 1425 (369–3031) 2702 (743–5679) 5004 (1331–10 489) 9145 (2449–18 834)
    Occupational exposure to polycyclic aromatic hydrocarbons 1638 (772–2817) 3092 (1394–5028) 492 (230–864) 993 (441–1661) 2130 (1018–3613) 4086 (1909–6567)
    Occupational exposure to silica 7870 (5154–11 902) 14 205 (8244–19 702) 1185 (797–1975) 2072 (1102–2948) 9056 (6140–13 213) 16 277 (9875–22 272)
    Occupational exposure to sulphuric acid 1964 (531–4383) 2606 (718–5761) 193 (55–452) 239 (74–509) 2157 (626–4707) 2845 (833–6109)
  Occupational asthmagens 31 666 (15 305–62 856) 25 364 (15 642–48 748) 10 485 (5116–19 129) 8352 (4854–13 425) 42 151 (24 425–76 872) 33 716 (22 844–58 659)
  Occupational particulate matter, gases, and fumes 207 366 (92 516–320 244) 171 553 (79 656–270 369) 68 281 (29 408–112 504) 47 311 (20 330–77 499) 275 647 (121 774–429 427) 218 864 (100 403–344 633)
  Occupational noise 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0)
  Occupational risk factors for injuries 400 064 (308 482–507 787) 460 785 (343 904–618 319) 21 211 (16 479–27 705) 20 644 (15 628–27 414) 421 275 (329 209–529 004) 481 429 (363 778–639 590)
  Occupational low back pain 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0)

Sexual abuse and violence 37 429 (21 366–56 607) 200 930 (113 070–292 802) 238 359 (143 200–325 690)
  Childhood sexual abuse 37 429 (21 366–56 607) 27 009 (14 290–43 424) 64 438 (37 339–94 174)
  Intimate partner violence 186 365 (92 028–280 059) 186 365 (92 028–280 059)

No data indicates that attributable deaths were not quantified.