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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Lancet. 2012 Dec 15;380(9859):2224–2260. doi: 10.1016/S0140-6736(12)61766-8

Table 4.

Disability-adjusted life-years (1000s) attributable to risk factors and risk factor clusters, worldwide

Men Women Both sexes



1990 2010 1990 2010 1990 2010
Unimproved water and sanitation 27 045 (1409–49 439) 11 022 (458–21 162) 25 123 (1262–45 792) 10 165 (428–19 650) 52 169 (2700–93 073) 21 187 (866–40 957)
  Unimproved water source 11 075 (792–21 250) 4080 (266–8172) 10 097 (722–19 424) 3694 (242–7511) 21 172 (1517–40 491) 7775 (514–15 705)
  Unimproved sanitation 18 610 (593–35 486) 7735 (190–15 338) 17 441 (522–32 889) 7192 (187–14 099) 36 050 (1115–66 871) 14 927 (377–29 705)

Air pollution
  Ambient particulate matter pollution 46 667 (40 185–53 381) 46 732 (41 393–52 602) 35 032 (29 974–40 402) 29 431 (25 722–33 273) 81 699 (71 012–92 859) 76 163 (68 086–85 171)
  Household air pollution from solid fuels 94 276 (73 721–113 071) 61 645 (45 944–77 497) 81 632 (66 415–96 472) 49 317 (38 818–60 315) 175 909 (141 870–207 095) 110 962 (86 848–137 813)
  Ambient ozone pollution 1409 (460–2456) 1440 (506–2563) 1125 (375–1990) 1016 (331–1758) 2534 (851–4426) 2456 (837–4299)

Other environmental risks 2876 (2406–3459) 9434 (7476–12 045) 2489 (1974–3015) 6617 (5322–7938) 5365 (4534–6279) 16 051 (13 212–19 503)
  Residential radon 1514 (191–3383) 600 (84–1355) 2114 (273–4660)
  Lead exposure 2876 (2406–3459) 7920 (6491–9683) 2489 (1974–3015) 6017 (4915–7231) 5365 (4534–6279) 13 936 (11 750–16 327)

Child and maternal undernutrition 175 366 (146 049–211 406) 83 202 (67 963–99 704) 164 599 (139 926–192 077) 82 894 (69 171–98 757) 339 965 (289 845–402 489) 166 095 (139 685–193 981)
  Suboptimal breastfeeding 59 902 (36 953–84 059) 25 572 (15 540–37 260) 50 359 (32 186–70 526) 21 965 (13 717–31 340) 110 261 (69 615–153 539) 47 537 (29 868–67 518)
    Non-exclusive breastfeeding 52 729 (30 540–75 288) 22 258 (12 464–32 936) 43 601 (26 173–62 072) 18 850 (10 926–27 569) 96 330 (57 274–135 861) 41 108 (23 668–58 913)
    Discontinued breastfeeding 7173 (767–15 819) 3314 (324–7377) 6758 (696–14 710) 3114 (296–6915) 13 931 (1443–30 062) 6429 (605–14 426)
  Childhood underweight 104 713 (87 668–128 697) 41 270 (33 478–50 007) 93 028 (78 656–112 766) 36 045 (29 430–43 394) 197 741 (169 224–238 276) 77 316 (64 497–91 943)
  Iron deficiency 21 451 (14 947–30 321) 19 974 (13 595–28 289) 30 390 (22 473–40 703) 28 251 (20 195–39 063) 51 841 (37 477–71 202) 48 225 (33 769–67 592)
  Vitamin A deficiency 15 689 (7475–29 165) 5672 (2904–9348) 14 598 (7068–25 637) 5098 (2566–8168) 30 288 (14 884–54 488) 10 770 (5625–17 149)
  Zinc deficiency 12 666 (2938–23 883) 4880 (1203–9316) 11 709 (2640–22 049) 4256 (1131–7821) 24 375 (5385–45 685) 9136 (2458–16 903)

Tobacco smoking (including second-hand smoke) 104 840 (91 849–119 255) 115 496 (98 595–130 090) 46 926 (39 634–58 092) 41 342 (30 473–48 563) 151 766 (136 367–169 522) 156 838 (136 543–173 057)
  Tobacco smoking 84 956 (73 038–97 937) 105 635 (88 332–120 347) 28 784 (21 829–40 090) 31 272 (19 859–38 467) 113 740 (100 454–131 675) 136 907 (117 201–153 778)
  Second-hand smoke 19 884 (14 493–25 591) 9861 (7669–12 312) 18 142 (13 748–22 355) 10 070 (7931–12 429) 38 026 (28 832–47 544) 19 931 (15 707–24 223)

Alcohol and drug use 88 000 (79 774–96 333) 119 130 (107 244–130 842) 33 648 (30 426–37 108) 42 178 (38 018–46 786) 121 648 (111 426–132 342) 161 308 (146 934–175 282)
  Alcohol use 77 550 (70 706–84 835) 101 875 (92 405–111 165) 28 479 (25 762–31 372) 34 188 (30 882–37 479) 106 029 (98 299–114 763) 136 063 (125 361–146 788)
  Drug use 10 178 (7787–13 073) 16 248 (12 679–20 132) 4993 (3811–6417) 7562 (5922–9471) 15 171 (11 714–19 369) 23 810 (18 780–29 246)

Physiological risk factors
  High fasting plasma glucose 30 177 (25 148–34 980) 49 148 (41 619–57 197) 26 181 (22 243–30 349) 39 864 (34 103–45 972) 56 358 (48 720–65 030) 89 012 (77 743–101 390)
  High total cholesterol 22 519 (18 230–27 029) 23 179 (17 148–29 650) 17 006 (13 940–20 640) 17 721 (13 153–22 508) 39 526 (32 704–47 202) 40 900 (31 662–50 484)
  High blood pressure 73 120 (65 538–81 302) 99 566 (88 193–110 943) 63 897 (57 903–70 789) 73 991 (66 161–81 931) 137 017 (124 360–149 366) 173 556 (155 939–189 025)
  High body-mass index 25 391 (19 752–31 108) 48 310 (39 429–57 750) 26 174 (20 911–31 642) 45 300 (37 218–54 219) 51 565 (40 786–62 557) 93 609 (77 107–110 600)
  Low bone mineral density 1764 (1448–2208) 3105 (2295–3831) 1361 (1102–1686) 2111 (1627–2618) 3125 (2589–3811) 5216 (4133–6418)

Dietary risk factors and physical inactivity 102 663 (94 539–111 011) 149 576 (138 035–160 263) 74 611 (68 196–81 173) 104 757 (97 047–112 535) 177 274 (164 710–190 286) 254 333 (237 748–270 495)
  Diet low in fruits 47 979 (37 530–57 842) 65 523 (51 056–78 959) 32 474 (25 061–39 155) 38 573 (29 923–46 512) 80 453 (63 298–95 763) 104 095 (81 833–124 169)
  Diet low in vegetables 18 755 (12 859–24 939) 24 169 (16 503–32 480) 12 803 (8412–17 503) 14 389 (9434–19 284) 31 558 (21 349–41 921) 38 559 (26 006–51 658)
  Diet low in whole grains 17 033 (13 513–20 522) 24 881 (19 486–29 709) 12 370 (9625–14 895) 15 881 (12 615–18 949) 29 404 (23 097–35 134) 40 762 (32 112–48 486)
  Diet low in nuts and seeds 24 918 (16 268–31 946) 32 615 (21 258–41 958) 15 607 (9915–20 208) 18 674 (11 716–24 404) 40 525 (26 308–51 741) 51 289 (33 482–65 959)
  Diet low in milk 818 (248–1366) 1171 (350–1977) 710 (210–1210) 931 (264–1605) 1527 (461–2555) 2101 (619–3544)
  Diet high in red meat 642 (306–1014) 1026 (484–1629) 566 (263–903) 827 (374–1362) 1208 (571–1909) 1853 (870–2946)
  Diet high in processed meat 10 477 (2801–17 479) 12 901 (4012–21 421) 6882 (2340–11 119) 8038 (2932–12 685) 17 359 (5137–27 949) 20 939 (6982–33 468)
  Diet high in sugar-sweetened beverages 3085 (2120–4151) 4858 (3154–6549) 2358 (1586–3484) 3695 (2356–5255) 5443 (3769–7373) 8553 (5823–11 418)
  Diet low in fibre 8485 (3787–13 262) 10 893 (4903–17 191) 4862 (2188–7562) 5559 (2500–8639) 13 347 (5970–20 751) 16 452 (7401–25 783)
  Diet low in calcium 1083 (752–1406) 1570 (1113–2058) 753 (521–975) 1019 (720–1319) 1836 (1316–2368) 2590 (1873–3322)
  Diet low in seafood omega-3 fatty acids 13 620 (9915–17 307) 18 300 (13 267–23 201) 8120 (5900–10 388) 9899 (7241–12 596) 21 740 (15 869–27 537) 28 199 (20 624–35 974)
  Diet low in polyunsaturated fatty acids 6185 (2891–9362) 7521 (3455–11 583) 3727 (1788–5709) 4159 (1973–6396) 9912 (4655–14 976) 11 680 (5360–17 798)
  Diet high in trans fatty acids 4979 (3571–6413) 7339 (5240–9300) 3085 (2226–3944) 4253 (3106–5416) 8064 (5893–10 305) 11 592 (8395–14 623)
  Diet high in sodium 26 807 (17 646–35 273) 37 378 (24 639–49 428) 19 376 (12 521–25 596) 23 852 (15 544–31 682) 46 183 (30 363–60 604) 61 231 (40 124–80 342)
  Physical inactivity and low physical activity 37 007 (30 583–43 466) 32 311 (27 698–37 217) 69 318 (58 646–80 182)

Occupational risk factors 42 660 (35 146–50 545) 48 317 (38 407–58 677) 12 754 (9357–16 658) 14 171 (10 344–18 842) 55 414 (45 312–66 718) 62 488 (49 471–76 240)
  Occupational carcinogens 1346 (917–1958) 2087 (1315–2928) 412 (284–611) 594 (368–855) 1758 (1220–2477) 2681 (1773–3689)
    Occupational exposure to asbestos 362 (236–555) 521 (279–709) 122 (78–189) 132 (61–184) 484 (354–695) 653 (389–840)
    Occupational exposure to arsenic 29 (11–56) 45 (17–84) 12 (5–24) 18 (7–33) 41 (16–77) 63 (24–114)
    Occupational exposure to benzene 36 (15–64) 52 (21–92) 28 (11–52) 40 (15–72) 65 (27–112) 92 (39–163)
    Occupational exposure to beryllium 2 (1–3) 3 (1–5) 1 (0–1) 1 (0–2) 2 (1–4) 4 (2–6)
    Occupational exposure to cadmium 5 (2–9) 10 (4–16) 2 (1–3) 3 (1–6) 7 (3–12) 13 (6–21)
    Occupational exposure to chromium 18 (11–28) 32 (17–48) 8 (4–13) 13 (7–21) 26 (16–40) 45 (27–66)
    Occupational exposure to diesel engine exhaust 278 (158–436) 442 (232–682) 54 (31–88) 81 (42–126) 332 (192–517) 523 (292–789)
    Occupational exposure to second-hand smoke 257 (173–383) 405 (244–544) 100 (69–162) 167 (95–228) 358 (255–500) 572 (386–762)
    Occupational exposure to formaldehyde 11 (4–20) 17 (6–31) 7 (3–13) 9 (4–16) 18 (8–32) 25 (11–47)
    Occupational exposure to nickel 90 (24–191) 151 (38–312) 37 (10–79) 64 (18–132) 128 (34–266) 215 (58–443)
    Occupational exposure to polycyclic aromatic hydrocarbons 41 (19–71) 73 (33–119) 13 (6–23) 23 (10–39) 54 (26–92) 96 (45–156)
    Occupational exposure to silica 199 (129–297) 333 (199–463) 31 (21–52) 49 (26–71) 230 (154–328) 382 (239–526)
    Occupational exposure to sulphuric acid 52 (14–114) 66 (19–143) 5 (1–12) 6 (2–13) 57 (16–122) 71 (21–152)
  Occupational asthmagens 1467 (874–2439) 1359 (917–2153) 662 (366–1062) 661 (407–994) 2129 (1419–3222) 2020 (1441–2871)
  Occupational particulate matter, gases, and fumes 6808 (3162–10 425) 6682 (3293–10 311) 2745 (1216–4406) 2460 (1105–4025) 9552 (4385–14 636) 9142 (4377–14 250)
  Occupational noise 1936 (1149–3103) 2284 (1348–3649) 933 (550–1489) 1167 (696–1870) 2869 (1698–4582) 3451 (2072–5574)
  Occupational risk factors for injuries 20 175 (15 588–25 639) 22 434 (16 711–29 943) 1090 (836–1437) 1010 (771–1331) 21 265 (16 644–26 702) 23 444 (17 736–30 904)
  Occupational low back pain 10 929 (7340–15 116) 13 471 (8968–18 945) 6912 (4487–9835) 8279 (5502–11 602) 17 841 (11 846–24 945) 21 750 (14 492–30 533)

Sexual abuse and violence 3588 (2669–4679) 19 931 (14 524–26 397) 23 519 (17 961–30 322)
  Childhood sexual abuse 3588 (2669–4679) 4244 (3082–5533) 7833 (5964–10 005)
  Intimate partner violence 16 794 (11 373–23 087) 16 794 (11 373–23 087)

No data indicates that attributable disability-adjusted life-years were not quantified. Total disability-adjusted life-years (in 1000s) in 1990 were 1 360 569 for men, 1 142 032 for women, and 2 502 601 for both. In 2010, they were 1 370 177 for men, 1 120 208 for women, and 2 490 385 for both.