Figure. Probability of cost-effectiveness of Treat All, Treat None and CAC screening strategies at different willingness to pay thresholds.
These acceptability curves illustrate probabilistic results from 10,000 model runs of the base case clinical scenario (a 55-year-old woman with high cholesterol), under both favorable and unfavorable statin assumption scenarios, that account for the uncertainty in parameter estimates described in Supplemental Table 1. The decision to measure CAC is sensitive to the willingness to pay threshold when unfavorable assumptions about statins are used. A disutility of .00384 is equivalent to 2 weeks of perfect health traded away to avoid 10 years on statins. CAC – Coronary artery calcium score; QALY – Quality-adjusted life-years