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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Prostate. 2014 Jul 7;74(12):1209–1221. doi: 10.1002/pros.22837

Fig. 4.

Fig. 4

Pharmacological inhibition of autophagy by 3-MA enhances HNK-mediated apoptosis. Effects of 3-MA and/or HNK treatments on A: Cell viability, B: DNA fragmentation, and C: PARP cleavage in PC-3 and LNCaP cells after 2 h pretreatment with 4 mM of 3-MA and then 24 h exposure to DMSO or 40 μM of HNK in the absence or presence of 3-MA. Results shown are mean ± SD (n = 3). *Statistically significant (panels A and B) between the indicated groups by one-way ANOVA followed by Bonferroni’s multiple comparison test.