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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Exp Biol Med (Maywood). 2014 Jun 9;239(9):1203–1214. doi: 10.1177/1535370214538589

Figure 4. Interaction of metabolic pathway with muscle differentiation.

Figure 4

MiR-696 is downregulated with exercise and motor nerve activity, which leads to an increase in peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1), a potent transcriptional coactivator that regulates genes involved in energy metabolism. PGC-1 increases Myocyte enhancer factor-2 (Mef-2) and nuclear respiratory factor (NRF), leading to increased type I myofiber formation and mitochondrial biogenesis/oxidative metabolism, respectively. The miR-696 pathway interacts with the previously described miR-133a pathway by way of Mef-2.106