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Endoscopic and histologic views of acute GvHD. A. Clinically normal duodenum. B. Moderate acute GvHD diagnosed by mild mucosal edema, hyperemia, villous blunting, and small erosions. C. H&E stain of normal human duodenum demonstrating normal crypt/villous architecture. D. H&E stain of acute GvHD showing architectural distortion, loss of crypts, lymphocytic infiltration with small hemorrhage (H), and crypt cell apoptosis.
