Fig. 5.

STZ-Mig6^+/− mice have preserved beta cell function. (a, b) Circulating insulin levels during a glucose challenge (a) Time course and (b) AUC are shown. n=8, *p<0.05 vs STZ-Mig6^+/+. (c, d) Blood glucose levels during ITT pre- and post-STZ treatment. (e–g) Pdx1, IRS2, and Ins2 mRNA levels in islets isolated from saline-injected Mig6^+/+, STZ-Mig6^+/− and STZ-treated Mig6^+/+ mice. Dotted lines indicate values for saline-injected Mig6^+/+ controls. n>5; *p<0.05 vs STZ-Mig6^+/+