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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Diabetologia. 2014 Jul 4;57(10):2066–2075. doi: 10.1007/s00125-014-3311-z

Fig. 6.

Fig. 6

MIG6 overexpression compromises beta cell integrity and islet function. (a–c) Isolated rat islets (n=3) were transduced with (a, b) CMV-GFP or CMV-MIG6 adenoviral vectors (*p<0.05 vs CMV-GFP) and (c) GSIS was assessed (white bars, low glucose; black bars, high glucose; *p<0.05 vs low glucose; †p<0.05 vs high glucose-stimulated CMV-GFP). (d–f) 832/13 cells were either transduced or not with CMV-GFP or CMV-MIG6 adenoviral vectors. Pdx1, IRS2 and Ins1/2 mRNA levels were determined. n=5, *p<0.05 vs untransduced or CMV-GFP