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MIG6 does not modulate the cytokine- or STZ-induced immune response. (a, b) Insulitis scoring (defined in Methods) of STZ-Mig6+/− and STZ-Mig6+/+ mouse pancreases. (a) Representative images of islets and (b) quantified results (white, 0; light grey, 1; dark grey, 2; black, 3). Scale bar, 100 µm. (c) Islets from Mig6+/+ (white bars) and Mig6+/− (black bars) were treated with cytokines and NO levels in islet culture medium was measured. n=3, *p<0.05 vs untreated
