MIG6 promotes DNA damage-induced beta cell death. (a) 832/13 cells were treated with doxorubicin for 6 h or with cytokines for the indicated times. Phospho (p)-p53, p53 and tubulin protein levels were determined. (b–d) 832/13 cells were transduced with siCon or siMig6 adenoviral vectors, and treated with vehicle (white bars) or CA (black bars). p-p53, p53, caspase- 3 and GAPDH protein levels were determined. n=3, *p<0.05 vs untreated, †p<0.05 vs siCon+CA