Table 3.
HLA allele association with SLE. Gene*Allele is the gene and four (two for DRB3-5) digit HLA allele assignment. OR with ±95% CI in parentheses and p values of association with SLE with three PCA axes. Only alleles with p ≤ 10−3 are shown.
| Gene*Allele | OR ± 95% CI | p | FDR |
|---|---|---|---|
| HLA-B*08:01 | 1.802 (1.346, 2.432) | 9.35 × 10−5 | 2.36 × 10−3 |
| HLA-DQA1*05:01 | 1.890 (1.534, 2.335) | 2.80 × 10−9 | 4.96 × 10−7 |
| HLA-DQB1*02:01 | 1.755 (1.381, 2.238) | 4.85 × 10−6 | 2.39 × 10−4 |
| HLA-DQB1*03:01 | 0.643 (0.502, 0.825) | 4.95 × 10−4 | 7.80 × 10−3 |
| HLA-DRB1*03:01 | 1.934 (1.507, 2.494) | 2.88 × 10−7 | 2.55 × 10−5 |
| HLA-DRB3*01 | 1.791 (1.296, 2.507) | 5.28 × 10−4 | 7.80 × 10−3 |
| HLA-DRB3*02 | 1.791 (1.296, 2.507) | 5.28 × 10−4 | 7.80 × 10−3 |