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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Neurochem. 2014 Jun 11;130(6):790–796. doi: 10.1111/jnc.12768

Figure 1. Sex-dependent effect of chronic morphine on the mRNA expression of MOR variants.

Figure 1

Male and female rats were treated with escalating doses of morphine base pellets (see methods). Data are calculated as fold change in MOR mRNA content, where 2−ΔΔCT represents the change in spinal mRNA content in opioid naïve (Nv) vs. chronic morphine treated (CM) groups relative to that of rMOR-1R. Chronic morphine significantly upregulated two splice variants of MOR, rMOR-1B2 (M-1B2) and rMOR-1C1 (M-1C1) in only males (*= ~ 2 fold; p<0.05). n=5-8).