Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Neurochem. 2014 Jun 11;130(6):790–796. doi: 10.1111/jnc.12768

Figure 2. Effect of chronic systemic morphine on MOR density in spinal cord of male rat.

Figure 2

Lumbar spinal tissue obtained from two placebo or chronic morphine-treated male rats were dissected and pooled for each saturation binding experiment using [3H]DAMGO. (A) Mean [3H]DAMGO Bmax±SEM was determined in spinal cord from naïve (109.5±3.0 fmol/mg protein) and chronic morphine treated (125.3±4.5 fmol/mg protein) groups (*p<0.05; n=6). Hatched portion indicates the increment in [3H]DAMGO Bmax following chronic-morphine treatment. (B) A representative scatchard plot is shown for naïve and chronic morphine-treated spinal cord. No significant difference was observed between [3H]DAMGO KDs in naïve (1.49±0.04 nM) and morphine-treated spinal cord (1.60±0.03 nM) group (p>0.05).