Figure 3. Normalized intensities (I/I₀) for the lipid PRE and solvent PRE sample.

Intensities are normalized by comparison to the intensity of the reference sample I₀, the smaller the ratio, the stronger the PRE effect is. I/I₀ of 0.1 mM gp41^27–194, 50 mM Na Ac pH4, 25mM KCl, 35 mM DPC plus a) 0.5 mM 5-DSA (final concentration) and c) 5 mM Gadodiamide (Omniscan) (final concentration). Normalized intensities are visualized for the NHR domain of 1ENV. Residues are color coded according to their lipid interactions and solvent exposure: b) blue for little lipid interactions (I/I₀> 0.93) to white for medium lipid interactions (I/I₀=0.71) to red for strong lipid interactions (I/I₀< 0.5) and d) blue for little solvent exposure (I/I₀> 0.77) to white for medium solvent exposure (I/I₀=0.61) to red for strong solvent exposure (I/I₀< 0.44).