Table 3. Drug interaction potential of the most utilized medications in U.S. patients with HCV by total number of prescriptions filled.
| Medication | Number of claims | Boceprevir* | Telaprevir* | ||||||
|---|---|---|---|---|---|---|---|---|---|
| None | Interaction | CI | NL | None | Interaction | CI | NL | ||
| 1. Acetaminophen/hydrocodone bitartrate | 367,166 | X§ | X§ | ||||||
| 2. Ribavirin | 176,842 | X | X | ||||||
| 3. Zolpidem tartrate | 169,811 | X | X | ||||||
| 4. Levothyroxine sodium | 155,926 | X | X | ||||||
| 5. Alprazolam | 146,362 | X | X | ||||||
| 6. Lisinopril† | 123,616 | X | X | ||||||
| 7. Peginterferon alfa-2a | 120,191 | X | X | ||||||
| 8. Oxycodone | 118,753 | X | X | ||||||
| 9. Furosemide | 100,413 | X | X | ||||||
| 10. Amlodipine besylate | 93,776 | X | X | ||||||
| 11. Omeprazole | 87,895 | X | X | ||||||
| 12. Acetaminophen/oxycodone | 81,332 | X§ | X§ | ||||||
| 13. Esomeprazole magnesium | 80,526 | X§ | X | ||||||
| 14. Metformin HCl† | 78,229 | X | X | ||||||
| 15. Escitalopram oxalate | 74,171 | X | X | ||||||
| 16. Spironolactone | 72,277 | X | X | ||||||
| 17. Hydrochlorothiazide | 71,311 | X | X | ||||||
| 18. Bupropion HCl | 66,680 | X | X | ||||||
| 19. Tramadol HCl | 65,803 | X | X | ||||||
| 20. Pantoprazole sodium | 62,622 | X | X | ||||||
| 21. Metoprolol succinate† | 61,663 | X | X | ||||||
| 22. Lorazepam | 59,950 | X | X | ||||||
| 23. Azithromycin | 59,784 | X | X | ||||||
| 24. Atenolol | 59,054 | X | X | ||||||
| 25. Peginterferon alfa-2b | 58,846 | X | X | ||||||
| 26. Sertraline | 58,004 | X | X | ||||||
| 27. Clonazepam | 57,336 | X | X | ||||||
| 28. Citalopram hydrobromide† | 55,375 | X | X | ||||||
| 29. Gabapentin | 53,583 | X | X | ||||||
| 30. Trazodone | 53,564 | X | X | ||||||
| 31. Prednisone | 53,292 | X | X | ||||||
| 32. Tacrolimus | 50,389 | X | X | ||||||
| 33. Amoxicillin | 49,285 | X | X | ||||||
| 34. Cyclobenzaprine | 48,168 | X | X | ||||||
| 35. Diazepam | 48,097 | X | X | ||||||
| 36. Potassium chloride | 47,627 | X | X | ||||||
| 37. Sulfamethoxazole/trimethoprim | 46,555 | X§ | X§ | ||||||
| 38. Venlafaxine | 46,376 | X | X | ||||||
| 39. Metoprolol tartrate† | 45,848 | X | X | ||||||
| 40. Carisoprodol | 45,149 | X | X | ||||||
Abbreviations: HCV, Hepatitis C Virus; CI, Contraindicated; NL, Not listed
*
Interaction potential based on Liverpool Drug Interaction charts[21] with None: “No clinically significant interaction expected”; Interaction: “Potential interaction – may require close monitoring, alteration of drug dosage or timing of administration; Contraindicated: “These drugs should not be coadministered”
†
Chart indicates drug-disease interaction only with hepatic insufficiency/cirrhosis and/or pharmacokinetic interaction unlikely
§
Interaction has not been assessed and has been predicted based on metabolic profiles of the drugs