Table 4. Liverpool resource recommendations for top medications reported to have interaction potential with boceprevir and telaprevir[21].

Medication	Classification*						Studied	Clear recommendation	Listed in prescribing information
	Boceprevir			Telaprevir
	N	I	C	N	I	C	BOC/TVR	BOC/TVR	BOC/TVR
zolpidem		X			X		No / Yes	No / Yes	No / Yes
alprazolam		X			X		Yes / Yes	Yes / Yes	Yes / Yes
amlodipine		X			X		No / Yes	Yes / Yes	Yes / Yes
prednisone		X			XC		Yes / No	YesPI / Yes	No / Yes
tramadol		X			X		No / No	No / No	No / No
codeine		X			X		No / No	Yes / Yes	No / No
fluticasone		XC			XC		No / No	Yes / Yes	Yes / Yes
methylprednisolone		X			XC		No / No	Yes / Yes	No / Yes
escitalopram		X			X		Yes / Yes	Yes / Yes	No / Yes
trazodone		X			X		No / No	Yes / Yes	Yes / Yes
clindamycin (systemic)		X			X		No / No	No / No	No / No
diazepam		X			X		No / No	No / No	No / No
sertraline		X			X		No / No	No / No	No / No
lansoprazole		X			X		No / No	No / No	No / No
clonazepam		X			X		No / No	No / No	No / No
sildenafil (Viagra only)		X			X		No / No	Yes / Yes	Yes / Yes
fluconazole		X			X		No / No	No / No	No / No
simvastatin			X			X	No / No	Yes / Yes	Yes / Yes
venlafaxine		X			X		No / No	No / No	No / No
salmeterol		XC			XC		No / No	Yes / Yes	Yes / Yes
clarithromycin		X			X		Yes / No	Yes / Yes	Yes / Yes
tacrolimus		X			X		Yes / Yes	Yes / Yes	Yes / Yes

Abbreviations: N, None; I, Potential interaction; C, Contraindicated; BOC, Boceprevir; TVR, Telaprevir; PI, prescribing information

^*Interaction potential based on Liverpool Drug Interaction charts with None: “No clinically significant interaction expected”; Potential interaction: “Potential interaction – may require close monitoring, alteration of drug dosage or timing of administration; Contraindicated: “These drugs should not be coadministered”

Bold indicates drug also listed in Table 3

^CAlthough drug is classified as potential interaction, recommendation is to avoid coadministration