TABLE 2.
Cytokine levels in sera of infected mice
| Cytokine | Mean cytokine level (pg/ml) ± SEMa at:
|
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 0
|
Day 1
|
Day 3
|
Day 5
|
Day 7
|
|||||||
| C57BL/6 | IL-6−/− | C57BL/6 | IL-6−/− | C57BL/6 | IL-6−/− | C57BL/6 | IL-6−/− | IL-6−/− + rIL-6 | C57BL/6 | IL-6−/− | |
| TNF-α | 9 | 8 | 17 ± 2* | 9 ± 0.8* | 11 ± 1* | 76 ± 3* | 13 ± 4* | 197 ± 16* | 92 ± 28 | 25 ± 4* | 590 ± 92* |
| IFN-γ | 0 | 1.5 | 17 ± 3* | 6 ± 1* | 3 ± 0.5* | 16 ± 5* | 7 ± 2* | 31 ± 2* | 14 ± 5 | 13 ± 0.8* | 40 ± 9* |
| MCP-1 | 19 | 40 | 140 ± 40 | 109 ± 15 | 85 ± 19* | 642 ± 70* | 113 ± 14* | 887 ± 95* | 288 ± 82 | 72 ± 2* | 3,643 ± 1200* |
| IL-10 | 0 | 0 | 0 | 69 ± 3 | 0 | 0 | 0 | 2,147 ± 1320 | 811 ± 475 | 0 | 154 ± 66 |
| IL-6 | 0 | 0 | 120 ± 21 | 0 | 134 ± 17 | 0 | 135 ± 11 | 0 | 0 | 213 ± 34 | 0 |
| IL-12p70 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
a
IL-6−/− mice were treated with 1 μg of rIL-6/day through the course of infection. An asterisk indicates a statistically significant comparison of at least P = 0.02 as determined by Mann-Whitney ANOVA.