FIG. 4.

Meningeal inflammation in experimental S. pneumoniae meningitis 36 h after infection. Mice were infected intracerebrally with 10⁴ CFU of S. pneumoniae in 25 μl of saline. ○ and open bars, Bcl-2-deficient mice (n = 8); ▪ and solid bars, controls (wild type [WT]) (n = 9). (A) Meningeal inflammation score (median and 25th and 75th percentiles). (B) Apoptotic PML in the meningeal infiltrate. (C) Apoptotic PML in cerebral infiltrate. The bars indicate means, and the error bars indicate standard deviations. No statistically significant differences were observed.