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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Genes Immun. 2014 Jun 5;15(6):413–423. doi: 10.1038/gene.2014.33

Figure 7. Long-term administration of low doses of rapamycin enhances memory CTLs to levels comparable to high doses.

Figure 7

Naïve WT or IL-12RKO OT-I cells were transferred into recipient B6 mice, which were infected with VV-OVA the next day. Low doses of rapamycin were administered daily between D-1 and D30 post VV-OVA infection, whereas high doses were administered between D-1 and D10 post-infection. OT-I populations were tracked in blood samples. A and C. Comparison of OT-I percentage of PBMCs at day 5 (A) or memory OT-Is in spleen at day 40 (C) after VV-OVA infection. B and D. Comparison of expression of CD62L in OT-Is in blood samples at D5 and D40 after VV-OVA infection. The results are representative of two separate experiments with similar results. Student’s t test was performed in A–D.