Table 2.
Average concentration of Fe, Cu, Zn and Mn in small hippocampal regions of the brain
| μg g−1wet weight | Control | WD | % change | p- value |
|---|---|---|---|---|
| Fascia dentata, layers | ||||
| Moleculare | ||||
| Fe | 13.1 ± 2.1 | 14.6 ± 1.2 | .1 | |
| Cu | 5.2 ± 1.2 | 8.9 ± 1.2 | +71% | .00001 |
| Zn | 14.0 ± 3.7 | 19.4 ± 1.3 | +38% | .004 |
| Mn | 0.34 ± 0.10 | 0.32 ± 0.07 | .9 | |
| Granulare | ||||
| Fe | 18.4 ± 3.4 | 16.3 ± 2.1 | .2 | |
| Cu | 4.1 ± 1.1 | 7.6 ± 1.0 | +86% | .00001 |
| Zn | 25 ± 7 | 32 ± 3 | +30% | .02 |
| Mn | 0.39 ± 0.14 | 0.39 ± 0.09 | .7 | |
| Multiforme /polymorph | ||||
| Fe | 12.9 ± 1.7 | 13.2 ± 0.8 | .7 | |
| Cu | 4.1 ± 1.2 | 8.0 ± 1.5 | +95% | .0001 |
| Zn | 47 ± 14 | 59 ± 9 | +24% | .1 |
| Mn | 0.48 ± 0.28 | 0.48 ± 0.14 | .8 | |
| Cornu ammonis, layers | ||||
| Oriens | ||||
| Fe | 10.8 ± 1.2 | 10.6 ± 1.0 | .7 | |
| Cu | 3.8 ± 0.8 | 6.6 ± 1.4 | +75% | .0002 |
| Zn | 18.0 ± 4.0 | 20.8 ± 3.8 | .2 | |
| Mn | 0.26 ± 0.06 | .32 ± 0.08 | .04 | |
| Pyramidale, CA3 | ||||
| Fe | 11.3 ± 1.9 | 12.3 ± 1.4 | .3 | |
| Cu | 4.6 ± 1.4 | 7.0 ± 1.2 | +52% | .003 |
| Zn | 33 ± 10 | 38 ± 5.5 | .2 | |
| Mn | 0.45 ± 0.20 | 0.48 ± 0.13 | .5 | |
| Pyramidale, CA1-2 | ||||
| Fe | 19.0 ± 3.7 | 15.1 ± 1.5 | .03 | |
| Cu | 3.5 ± 1.0 | 5.9 ± 0.9 | +69% | .0002 |
| Zn | 20.9 ± 4.8 | 24.4 ± 3.4 | .1 | |
| Mn | 0.27 ± 0.07 | 0.33 ± 0.06 | .04 | |
| Radiatum | ||||
| Fe | 10.5 ± 1.5 | 10.2 ± 0.7 | .7 | |
| Cu | 3.2 ± 0.8 | 6.3 ± 1.2 | +92% | .00002 |
| Zn | 21.8 ± 4.9 | 23.8 ± 3.0 | .3 | |
| Mn | 0.25 ± 0.06 | 0.31 ± 0.08 | .04 | |
| Lacunosum- moleculare | ||||
| Fe | 12.8 ± 2.1 | 12.2 ± 1.3 | .6 | |
| Cu | 3.6 ± 0.9 | 5.6 ± 1.0 | +53% | .001 |
| Zn | 14.1 ± 3.7 | 18.4 ± 1.5 | +30% | .01 |
| Mn | 0.28 ± 0.08 | 0.29 ± 0.06 | .4 | |
| Subiculum | ||||
| Fe | 14.4 ± 2.3 | 12.9 ± 1.4 | .2 | |
| Cu | 3.4 ± 0.9 | 5.9 ± 1.1 | +72% | .0001 |
| Zn | 15.4 ± 4.1 | 17.4 ± 1.6 | .2 | |
| Mn | 0.23 ± 0.06 | 0.27 ± 0.03 | .7 | |
| Praesubiculum | ||||
| Fe | 13.9 ± 3.2 | 13.8 ± 1.5 | 1 | |
| Cu | 4.8 ± 1.4 | 7.8 ± 1.4 | +62% | .0006 |
| Zn | 13.1 ± 3.0 | 16.3 ± 1.0 | +25% | .02 |
| Mn | 0.23 ± 0.07 | 0.26 ± 0.05 | .2 | |
Concentrations of Fe, Cu, Zn, Mn (mean ± SD) measured by LA-ICP-MSI in subregions of the hippocampal formation. Layers are given in the order from outside to inside.