Table 4.
Factors | Overall Survival (OS) | Disease-free Survival (DFS) | |||||
---|---|---|---|---|---|---|---|
Univariate | Multivare | Univariate | Multivariate | ||||
P | HR (95% CI) | P | P | HR (95% CI) | P | ||
Characteristic of | Age: >50 vs. ≤50 years* | 0.719 | NA | 0.981 | NA | ||
Demography, | Gender: male vs. female | 0.846 | NA | 0.088 | NA | ||
Tumor & | Tumor size: >5 vs. ≤5 cm | 0.061 | NA | 0.130 | NA | ||
Laboratory | Tumor number: multiple vs. single | 0.221 | NA | 0.192 | NA | ||
Tests | Serum AFP: ≥400 vs. <400 ng/ml | 0.285 | NA | 0.382 | NA | ||
Serum CA199 ≥ 37 vs. < 37 U/ml | 0.798 | NA | 0.236 | NA | |||
TNM stage: I/II vs. III | 0.030* | NS | 0.001* | 1.817 (1.135-2.909) | 0.013* | ||
Edmondson grade: I/II vs. III/IV | 0.074 | NA | 0.043* | NS | |||
Macrovascular Invasion: P vs. N | 0.014* | NS | 0.114 | NA | |||
Tumor encapsulation: absence vs. presence | 0.791 | NA | 0.311 | NA | |||
Histology: | Ishak grade >7 vs. ≤ 7 | 0.058 | NA | 0.072 | NA | ||
Peritumor | Ishak stage >5 vs. ≤ 5 | 0.096 | NA | 0.120 | NA | ||
PI-DR ≥ 50% vs. <50% | <0.001* | 3.316(1.961-5.610) | <0.001* | <0.001* | 2.618(1.701-4.029) | <0.001* | |
K7-DR ≥ 50% vs. <50% | 0.045* | 1.863(1.008-3.443) | 0.047* | 0.158 | NA | ||
EpCAMPeritumor Expression H vs. L* | 0.319 | NA | 0.003* | NS | |||
OV6Peritumor Expression H vs. L* | 0.191 | NA | 0.702 | NA | |||
C-kitPeritumorExpression H vs. L* | 0.721 | NA | 0.935 | NA | |||
CD133Peritumor Expression H vs. L* | 0.051 | NA | <0.001* | NS | |||
Histology: | Microvascular invasion: P vs. N | 0.327 | NA | 0.595 | NA | ||
Tumor: | EpCAM Expression H vs. L* | 0.017* | NS | 0.093 | NA | ||
OV6 Expression H vs. L* | 0.756 | NA | 0.034* | NS | |||
C-kit Expression H vs. L* | 0.352 | NA | 0.127 | NA | |||
CD133 Expression H vs. L* | 0.394 | NA | 0.091 | NA |
P, positive; N, negative; H, High; L, Low; NA, not adopted; NS, not significant;AFP, alpha-fetoprotein; ALT, alanine aminotransferase; CA19-9, carbohydrate antigen 19–9; CI, confidence interval; PI-DR, proliferative index of ductular reaction; DR, ductular reaction; EpCAM, epithelial cell adhesion molecule; HCC, hepatocellular carcinoma; HR, hazard ratio; K7-DR, Keratin 7 immunoreactive ductular reaction; TNM, tumor-node-metastasis;
*Medians were used for cutoff values.