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. 2014 Sep 2;107(5):1185–1195. doi: 10.1016/j.bpj.2014.07.026

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(A) Shear-rate dependency of platelet pause times on normal (WT A1), type 2B (P1337L), and type 2M (A1437T) variants. (B) Rank order of pause times at 1500 s⁻¹ shear rate from least to greatest. The type 2M variants F1369I, E1359K, I1425F, S1285F, and R1374H did not bind platelets at any shear rate. (Solid) Natively structured variants. (Dark shaded) Nativelike variants. (Light shaded) Molten globule variants. (Open) RCAM A1 represents a case of firm adhesion with no platelet translocation due to loss of the disulfide bond (19). Shear-rate dependency of platelet pause times on (C) natively structured type 2B A1 domain variants, (D) natively structured type 2M A1 domain variants, and (E) molten globule A1 domain variants. To see this figure in color, go online.