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. 2014 Aug 18;111(35):E3669–E3678. doi: 10.1073/pnas.1405798111

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Fig. 1. — ROS deficiency enhanced mannan-induced PsA. The arthritic joint phenotype and Ps-like skin lesions in the front (A) and hind (B) paws of B10Q.Ncf1^m1j/m1j mice are shown. (C) Ps-like skin scaling in diseased B10Q.Ncf1^m1j/m1j mouse ear compared with naive mouse ear. Mean arthritis (D) and Ps lesion (E) severity in B10Q (n = 5) and B10Q.Ncf1^m1j/m1j (n = 5) mice after a single i.p. mannan injection. Mean arthritis (F) and Ps lesion (G) severity in B10Q (n = 5) and B10Q.Ncf1^m1j/m1j (n = 5) mice after repetitive mannan injections (days 7 and 14). (H) Mannan-induced mean maximum arthritis scores ± SEM in different mouse strains: B10Q (n = 8), B10Q.Ncf1^m1j/m1j (n = 9), B10RIII (n = 10), B10RIII.Ncf1^m1j/m1j (n = 9), B10P (n = 3), B10P.Ncf1^m1j/m1j (n = 9), BALB/cByJ/Q (n = 10), BALB/cByJ/Q.Ncf1^m1j/m1j (n = 8), BALB/cByJ (n = 5), BALB/cByJ.Ncf1^m1j/m1j (n = 7), C57BL/6NJ (n = 8), and C57BL/6NJ.Ncf1^m1j/m1j (n = 7). Significance was calculated by comparing the maximal disease severity of B10Q and B10Q.Ncf1^m1j/m1j mice with all of the other strains in their respective groups. *P < 0.05; **P < 0.01; ***P < 0.001.