Fig. 4.
Cross-population analysis of selection signatures for pygmy phenotype-associated genomic regions. (A) Boxplot and fold-change comparisons of |iHS| and median FST values for SNPs located inside (In) vs. outside (Out) the 16 Batwa pygmy phenotype-associated regions identified by admixture mapping and supported by GEMMA (21). P values were computed with Wilcoxon tests. Fold-change = (median In − median Out)/median In. (B) Similar comparisons of |iHS| and median FST values for SNPs located inside versus outside 66 genomic regions previously reported to be associated with stature variation among west central African rainforest hunter-gatherers (6, 29). The Batwa are east central African rainforest hunter-gatherers and the Baka are west central African rainforest hunter-gatherers. The Bakiga and Nzebi/Nzime, respectively, are their Bantu-speaking agricultural neighbors.