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. 2004 Jun;72(6):3315–3324. doi: 10.1128/IAI.72.6.3315-3324.2004

FIG. 7.

FIG. 7.

Passive immune protection against C. rodentium. Mice deficient for pIgR were infected orally with C. rodentium (○) or left uninfected (•), and sera were collected after 6 weeks and tested for anti-C. rodentium antibodies by isotype-specific ELISA (A). Naive C57BL/6 mice (B and D) or pIgR-deficient mice (C) were infected orally with C. rodentium and injected intraperitoneally on days 4 to 7 and 11 to 14 with identical volumes of immune (Imm Ig), preimmune (Pre Ig), or IgG-depleted immune sera (Imm Ig-IgG). Bacterial numbers (CFU) in the feces were determined on days 7 (B) and 14 to 18 (B to D). Results are the mean ± standard deviation of quadruplicate samples (A) or mean ± standard error of six or more mice (B to D). OD450, optical density at 450 nm. *, P < 0.05 (by t test) relative to preimmune Ig-injected mice at the same time point.