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Depiction of changes affecting presynaptic (Upper) and postsynaptic indices (Lower) observed in the three experimental conditions. (Upper) TH volume (Left) is halved by EtOH-W and unaltered by EtOH-CHR, whereas DAT (Right) is unmodified by treatments. (Lower) Long thin spine density (Left) is reduced by about 40%, and this effect is paralleled by a reduction in PSD-95 (Right) immunolabeling of similar proportions (∼60%). *P < 0.0001 vs. CTRL. Error bars represent SEM in all figures.
