FIG. 3.

Survival analysis and bacterial loads of mice infected with wild-type S. enterica serovar Typhimurium and an isogenic metC::aacC1 mutant. C57BL/6J mice were infected with wild-type S. enterica serovar Typhimurium intravenously (10³ CFU) (A) or orally (10⁵ CFU) (B) (five males and five females for intravenous infections and five males and four females for oral infections) or with the metC::aacC1 mutant strain (five males and six females for intravenous infections and four males and five females for oral infections). Survival curves are representative of mice infected with the wild type (solid line) and the metC::aacC1 mutant (dashed line). The survival analysis was repeated two times, with similar results. (C) C57BL/6J mice were infected with 10³ CFU of wild-type S. enterica serovar Typhimurium (white bars) or the metC::aacC1 mutant strain (hatched bars). Each bar represents the data for groups of four mice (two males and two females). Results are expressed as means + 1 standard deviation.