TABLE 4.
MCPS Ag surface | Vaccine | % Inhibition with MAb
|
|||
---|---|---|---|---|---|
2055.5 | 2016.3 | C2/1076.10 | C2/256.8 | ||
OAc+ | Vac1 | 25b | 28c | 84b | 31 |
Vac2 | 16c | 20 | 88b | 68b | |
Vac3 | 17c | 21 | 84b | 25 | |
OAc− | Vac1 | 8 | 31c | 62b | 102c |
Vac2 | 7 | 32c | 68b | 118b | |
Vac3 | 7 | 37b | 75b | 69b |
Inhibition of conjugate vaccine immune sera binding to OAc+ and OAc− surfaces by anti-MCPS MAbs was calculated by the following equation: percent inhibition = (RU with MAb − RU with MAb control surface)/(RU − RU control surface). Duplicate experiments with 1/20 serum dilution were evaluated. Significance was assessed for RU with MAb versus RU without MAb using the Tukey-Kramer HSD and Student t tests.
Inhibition significant at a P value of < 0.05 by Tukey-Kramer HSD test for multiple comparisons in each Ab group.
Inhibition significant at a P value of <0.05 by paired Student t test.