Table 4. Cross Metathesis of Amino Acids 3 and 5a.
yielda (%) |
Z selectivityb (%) |
|||||
---|---|---|---|---|---|---|
entry | equiv of 3 | equiv of 5a | 1 | 2 | 1 | 2 |
1 | 1 | 1 | 41 | 47 | 90 | 93 |
2 | 1 | 2 | 44 | 48 | 86 | 91 |
3 | 1 | 4 | 48 | 41 | 91 | 90 |
4 | 1 | 6 | 58 | 60 | 88 | 90 |
5 | 2 | 1 | 44 | 58 | 90 | 93 |
6 | 4 | 1 | 52 | 57 | 91 | 91 |
7 | 6 | 1 | 51 | 60 | 87 | 90 |
Isolated yields.
Determined by 1H or 13C NMR spectroscopy.