Table 5. Cross Metathesis of Amino Acids 3 and 5s.
yielda (%) |
Z selectivityb (%) |
|||||
---|---|---|---|---|---|---|
entry | equiv of 3 | equiv of 5s | 1 | 2 | 1 | 2 |
1 | 1 | 1 | 46 | 47 | 90 | 93 |
2 | 1 | 2 | 43 | 48 | 84 | 90 |
3 | 1 | 4 | 38 | 41 | 84 | 91 |
4 | 1 | 6 | 34 | 38 | 72 | 88 |
5 | 2 | 1 | 47 | 58 | 88 | 91 |
6 | 4 | 1 | 58 | 60 | 90 | 92 |
7 | 6 | 1 | 62 | 66 | 87 | 90 |
Isolated yields.
Determined by 1H or 13C NMR spectroscopy.