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. 2014 Aug 7;136(35):12469–12478. doi: 10.1021/ja507166g

Table 9. RCM to Form i, i + 3 Stapled Peptides.

graphic file with name ja-2014-07166g_0013.jpg

entry substrate product catalyst (mol %) temperature (°C) time (h) conversiona (%) selectivity
1 20 21 22 (10) 45 10 86 >20:1 E/Zb
2     23 (10) 45 10 85 >20:1 E/Zb
3     1 (30) 40 21 <5 n.d.
4 24 25 22 (10) 45 3.5 100 13:1 E/Za
5     23 (10) 45 3.5 94 11:1 E/Za
6     1 (10) 40 4 <5 n.d.
a

Determined by analytical HPLC-MS.

b

Determined by 1H NMR spectroscopy.