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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: J Control Release. 2014 Mar 31;191:24–33. doi: 10.1016/j.jconrel.2014.03.041

Figure 4. Conjugation enhances antigen delivery to lymph node APCs.

Figure 4

C57Bl/6 mice were immunized with free ova, mixture, or conjugates in the dorsal part of the foot and draining popliteal lymph nodes isolated 90 min and 24 h post injection. a,b) Uptake of fluorescent ova in total lymphocyte populations as measured by flow cytometry. One-way ANOVA followed by Tukey’s Multiple Comparison Test was used for statistical analysis at a level of p < 0.05 with * indicating significance as compared to Ova-(HP-PDB). c,d) Uptake of ova in individual lymphocyte cell subtypes. Data shown are from two independent experiments with n = 6 mice per group, mean ± SEM. * = p < 0.05, one-way ANOVA followed by Tukey’s Multiple Comparison Test.