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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: J Control Release. 2014 Mar 31;191:24–33. doi: 10.1016/j.jconrel.2014.03.041

Scheme 1. Nanoparticle vaccine based on pH-responsive polymers for antigen delivery.

Scheme 1

Amphiphilic diblock copolymers were synthesized by controlled Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization and consist of a neutral, hydrophilic corona segment with pendant pyridyl disulfide groups for reversible antigen conjugation, and a hydrophobic, pH-responsive core that drives endosomal membrane destabilization. The carrier self-assembles into 25–30 nm micelles under aqueous conditions.