Table 3.

Classification of myocardial infarction in SPRINT ⁵¹. Definite indicates definite myocardial infarction; Probable, probable myocardial infarction; Possible, possible myocardial infarction; and No, no myocardial infarction. Classification of case is at highest level allowed by combinations of 3 characteristics (cardiac signs and symptoms, ECG findings, biomarkers).

ECG Findings*	Biomarker findings
	Cardiac symptoms or signs present				Cardiac symptoms or signs absent
	Diagnostic†	Equivocal†	Missing†	Normal†	Diagnostic	Equivocal	Missing	Normal
Evolving diagnostic	Definite	Definite	Definite	Definite	Definite	Definite	Definite	Definite
Positive	Definite	Probable	Probable	No	Definite	Probable	Possible	No
Nonspecific	Definite	Possible	No	No	Definite‡	Possible	No	No
Negative for evolving ischemia	Definite	Possible	No	No	Definite‡	No	No	No

^*See Tables 2–4 of Leupker et al⁵¹.

^†Biomarkers include CK, CK-MB, CK-MBm, and troponin (cTn) with diagnostic value increasing from CK to CK-MB to CK-MBm to troponin. Diagnostic is at least one positive biomarker (≥2×ULN) in an adequate set of biomarkers showing a rising or falling pattern in the setting of clinical cardiac ischemia and the absence of non-cardiac causes of biomarker elevation. Equivocal is present but not diagnostic.

^‡In absence of diagnostic troponin, downgrade to possible.