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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: J Control Release. 2014 Jul 19;191:90–97. doi: 10.1016/j.jconrel.2014.07.038

Figure 4.

Figure 4

Evaluation of tumor response to photo-thermal therapy by bioluminescence imaging. The bioluminescence signal is generated only in living cancer cells as result of luciferase activity. The mice treated with laser and nanomatryoshka (NM) or nanoshells (NS) experienced loss of bioluminescence in the area illuminated by the laser spot as seen 1 day after therapy. However, there were viable cancer cells in the edges of the tumor post therapy, which cause tumor recurrence for the highly aggressive cell lines used in this experiment. Mice were euthanized when tumor volume reached 2000 mm3.