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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: J Control Release. 2014 Jul 19;191:90–97. doi: 10.1016/j.jconrel.2014.07.038

Figure 5.

Figure 5

Histopathology of tumor sections extracted from mice intravenously injected with gold nanoparticles or control saline solution. (Left panel) Fluorescence staining combined with dark field microscopy: cell nucleus is stained with DAPI in blue; cell cytoplasm stained with Alexa Fluor® 594 in red and gold nanoparticle can be observed as yellow bright spots due to the nanoparticle scattering in the dark field mode. (Right panel) Hematoxyline and Eosine (H&E) staining. The cell morphology in all non-treated tumors, specially the nucleus, is observed intact. However, after laser treatment in presence of gold nanomatryoshkas or nanoshells the cell morphology is disrupted.