TABLE 4.

Comparison of antibody isotypes in responders to RAMA-E among individuals susceptible to and protected against P. falciparum infection during the course of the study

Antibody isotype	Prevalencea			Antibody levelb
	Protected (n = 25)	Susceptible (n = 41)	Pc	Protected (n = 25)	Susceptible (n = 41)	Pd
IgG1	92	80.49	0.296	0.140 (0.130, 0.465)	0.110 (0.030, 0.170)	0.0161
IgG2	32	21.95	0.396	0.020 (0.005, 0.045)	0.020 (0.000, 0.030)	0.4034
IgG3	88	68.29	0.083	0.160 (0.130, 0.295)	0.030 (0.010, 0.095)	0.0003
IgG4	12	17.07	0.730	0.000 (0.000, 0.010)	0.000 (0.000, 0.010)	0.7959
IgM	60	43.90	0.310	0.050 (0.005, 0.240)	0.010 (0.000, 0.140)	0.1502

^aPercentage of positive sera defined as those that gave OD values greater than the cutoff OD.

^bAntibody levels are presented as median OD values (lower quartile, upper quartile).

^cAntibody prevalences of protected and susceptible groups were compared using Fisher's exact test.

^dAntibody levels of protected and susceptible groups were compared using the Mann-Whitney test.